Study On Serum Vitamin D Level In Patients With Chronic Urticaria And Eczema In Guangdong

Vitamin D is a kind of essential vitamins,as well as a important member of the fat-soluble steroid derivatives family.90%of the vitamin D in human bodies are synthetized in the skin,with the action of ultraviolet irradiation.The metabolites of vitamin D are transported to the target organs through blood circulation,where they combine to the vitamin D receptor(VDR)and produce their biological effect.The existing researches tend to treat vitamin D as a precursor hormone,which role in the skeletal muscle health has also been acknowledged by many scholars.Moreover,recent studies have found that vitamin D also plays an important role in the pathogenesis of immune regulation and allergy related diseases.It may be of great benefit to chronic urticaria,eczema and other allergic related skin diseases by enhancing the skin's defence against microbes,inhibiting the inflammatory response of innate and adaptive immune systems.Vitamin D deficiency may be associated with chronic urticarial and eczema.This hypothesis has also been confirmed by some observational studies and small sample interventional studies,but there are still some conflicting viewpoints.Given that vitamin D status in human body may be affected by various factors such as race,age,sex,food and ultraviolet radiation,more evidence-based medical studies are needed to illustrate the relationship between vitamin D and these allergic diseases.In this study,we collected 62 chronic urticarial patients,124 eczema patients(including 39 atopic eczema,85 non-atopic eczema),who came to the dermatologist department in our hospital,from 2016-Jan-1 to 2017-Jan-1.The Healthy controls from the same hospital at the same time.Their serum total 25 hydroxyvitamin D levels were examined.After excluding the Confounding factors such as season,age,gender and so on,we compared their levels of serum total 25 hydroxyvitamin D with the statistical software SPSS 22.0 for data analysis.The results are as follows:1.In patients who are older than 45 years,there was no statistical difference between the Chronic urticaria group and control group in mean Average age and gender distribution.The serum total 25-hydroxyvitamin D level in patients with chronic urticaria was significantly lower than that in the healthy control group,and the difference was statistically significant.2.In patients who are older than 45 years,there was no statistical difference between the eczema group,non-atopic eczema group and the control group in mean age and sex distribution.The levels of serum 25 hydroxyl total vitamin D in the non-atopic eczema group and the atopic eczema group were significantly lower than that in the healthy control group,and this difference was statistically significant.Whereas no significant difference in serum total 25 hydroxyvitamin D levels was showed in the non-atopic eczema group and the atopic eczema group.The proportion of vitamin D deficiency in non-atopic eczema and atopic eczema group was higher than that in healthy control group,and the difference was statistically significant.Conclusion:The serum total 25 hydroxyvitamin D levels in chronic urticaria,non-atopic eczema,atopic eczema patients were significantly lower than that in the healthy control group.And the proportion of patients with vitamin D deficiency was also higher in these three groups than that in the healthy control group.It is suggested that low vitamin D status may be related to chronic urticaria and eczema,and correcting the low vitamin D status may be benefit for alleviating the symptoms,preventing recurrences,and improving the prognosis in these two diseases.To prove this point,larger-sample,well-designed observational and randomized controlled intervention studies are strongly needed.