The Therapeutic Effect Of Xiaoyaosan On Type 2 Diabetes Mellitus-depressive Disorder

ObjectiveThis paper focuses on patients suffering' liver depression and spleen deficiency of type 2 diabetes mellitus-depressive disorder.It studies the influence of Xiaoyaosan on these patients' relative data,including Self rating Depression Scale,Hamilton Depression Scale,Traditional Chinese medicine symptom score,and their indexes,including cortisol,adrenocor--ticotropic hormone,fasting plasma glucose,postprandial glucose,glycated hemoglobin.This paper reflects the effect of Xiaoyaosan objectively and accurately and provides more powerful evidences for clinical application of Xiaoyaosan on diabetes mellitus-depression disorder.MethodsThe patients with type 2 diabetes mellitus-depressive disorder who met the standard were selected.They were form the outpatient and inpatient of the Department of Endocrinology of the Second Traditional Chinese Medicine Hospital of Guangdong province from April 2017 to December 2017.Under the basic requirements of case estimation,the subjects were randomly divided into Chinese medicine treatment group and control group,40 cases in each one.Both were treated in conventional treatment on diabetes mellitus.The control group was treated with Escitalopram Oxalate Tablets;the treatment group was given Xiaoyaosan in the western medicine treatment.Data including Self rating Depression Scale,Hamilton Depression Scale,Traditional Chinese medicine symptom score,and indexes including cortisol,adrenocorticotropic hormone,fasting plasma glucose,postprandial glucose,and glycated hemoglobin were recorded before treatment and 6 weeks after treatment.The differences of examination data before and after treatment were compared between the two groups.Results1.Before treatment,indexes,including FPG,postprandial glucose and glycated hemoglobin of both two groups were not statistically significant(P>0.05),which was comparable.After treatment,fasting plasma glucose and postprandial glucose of two groups have significantly decreased in FPG(P<0.05).Compared to the control group,the treatment group had statistically significant difference(P<0.05).There was no significant difference in glycated hemoglobin between the two groups before and after treatment(P>0.05).2.Before treatment,there was no significant difference in the level of C-peptide between the control group and the treatment group(P>0.05).After treatment,the average C-peptide level of both two groups increased,but there was no significant difference.There was no significant difference in C-peptide between the two groups before and after treatment(P>0.05).3.Before treatment,there was no significant difference in cortisol and adrenocorticotropic hormone between the two groups(P>0.05).After treatment,COR and adrenocorticotropic hormone levels were significantly lower than those before treatment,with statistical significance(P<0.05).Especially in the treatment group,the decrease was clearer,more statistically significant than it in the control group(P<0.05).4.Before treatment,there was no statistically difference in Self rating Depression Scale and Hamilton Depression Scale of both two groups(P>0.05),which was comparable.After the treatment,scores of Self rating Depression Scale and Hamilton Depression Scale of the two groups were significantly decreased(P<0.01),and there was statistically significant difference between the two groups(P<0.01).5.Before treatment,there was no statistical difference in Traditional Chinese medicine symptom score between the two groups(P>0.05).After treatment,the Traditional Chinese medicine symptom scores in the two groups were decreased compared with ones before treatment(P<0.01).Especially in the treatment group,the decrease was significantly clearer than it in the control group(P<0.01).6.Before and after treatment,there was no statistical difference in alanine transaminase and aspartate transaminase between the two groups,neither between the two groups(P>0.05).After treatment,Rating Scale Side Effect was used to evaluate and showed that scores in the treatment group was significantly lower than that in the control group,which was statistically available(P<0.01).Conclusion:1.Xiaoyaosan can effectively reduce fasting plasma glucose,having better control on postprandial glucose;2.Xiaoyaosan has greater efforts on the decrease of adrenocorticotropic hormone and cortisol;3.Xiaoyaosan can better reduce the score in Self rating Depression Scale and Hamilton Depression Scale of patients and has better antidepressant effect;4.Xiaoyaosan can effectively alleviate the Traditional Chinese medicine symptoms of patients;5.Xiaoyaosan has no adverse damage to the liver function;.6.Xiaoyaosan can reduce discomfort after having antidepressants of patients.