| ObjectiveBy comparing the efficacy of Jing-moxibustion and grain-shape moxibustion in the treatment of knee osteoarthritis,the difference in the curative effect of two kinds of moxibustion is evaluated,which provides an objective basis for the effectiveness of Jing-moxibustion in treating knee osteoarthritis.MethodsFrom December 2016 to July 2017,70 patients with knee osteoarthritis were enrolled in the study.They were randomly divided into grain-shape moxibustion group and Jing-moxibustion group.Each group included 35 cases.The two groups were treated according to the following points.Because two kinds of moxibustion were done directly on skin,skin was stimulated to a certain extent.Two groups as follow were alternately used.(1)EX-LE5,ST36,BL14,BL20,BL28(2)EX-LE2,GB33,SP9,BL15,BL19,BL23The group of Jing-moxibustion: Wipe a small amount of oil on the corresponding points,and put Jing-moxibustion on the points(0.2cm in diameter and 0.3cm in height).After that,burn the top of Jing-moxibustion with incense sticks.Remove Jing-moxibustion with tweezers when patients feel burning pain.Each point should be operated two times.If adverse reactions appear,follow adverse reaction treatment steps.Grain-shape moxibustion group: Wipe a small amount of oil on the corresponding points,and put Grain-shape moxibustion on the points(0.5cm in diameter and 0.8cm in height).The follow operation is the same with Jing-moxibustion group.The course of treatment was 35 days,2 times a week.Select one of the point groups alternately.There were 10 treatments to complete.8 times ofaccomplishment were valid.The Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)was used as the primary outcome measures.The Medical Outcomes Study 36-Item Short-Form Health Survey(SF-36)was used as the secondary outcome measure,and the WOMAC scale score was used to evaluate the efficiency.Observe and record the adverse reactions and side effects of this study.Before treatment,at the end of treatment,one month after the end of treatment were time points for evaluation.Statistical analysis of the data was performed using SPSS 21.0 software.Measurement was expressed as`c±S,count data was expressed as a percentage(%).Measurement comparison between two groups was performed by t-test if normal distribution and homogeneity of variance were accorded.If one of the conditions was not accorded,rank sum test was used.Repeated measures analysis of variance was used for intra-group comparison.Count data comparison between two groups was performed by Chi-square test or Fisher exact probability test.The comparison of validity was performed by rank sum test.Test level is 0.05,two-sided test.Results1.Case completion: A total of 70 cases were enrolled in this study.All of them were effective cases.7 cases of them were exfoliated,1 case was excluded,so the total exfoliation rate was 10.00% and the total removal rate was 1.43%.There were 35 cases in the grain-shape moxibustion group,4 cases of them were exfoliated,the rate of exfoliation was 11.43%,while 1 case was removed and the removal rate was 2.86%.35 cases were involved in the Jing-moxibustion group.3 cases were shed,and the shedding rate was 8.57%.2.Baseline comparison: The general data comparison: the comparison of grain–shape moxibustion group and Jing-moxibustion group had no statistically significant difference in gender,education,occupation,TCM classification,age and disease duration(P﹥0.05).There was no significant difference in the scores of WOMAC scale and SF-36 before the treatment in the grain–shape moxibustion group and Jing-moxibustion group(P﹥0.05).Two sets of baseline was comparable.3.Outcome analysis3.1 WOMAC scaleThe results suggested that at the end of treatment and at 1 month follow-up,both groups decreased in the WOMAC score(P﹤0.05),and the score of Jingmoxibustion group decreased more than the other group(P﹤0.05).3.2 The Medical Outcomes Study 36-Item Short-Form Health Survey(SF-36)3.2.1 PF dimensionThe results suggested that at the end of treatment and at 1 month follow-up,both groups increased in the score of PF(P﹤0.05),and the score of Jingmoxibustion group increased more than the other group(P﹤0.05).3.2.2 RP dimensionThe results suggested that at the end of treatment,both groups increased in the score of RP(P﹤0.05).There was no significant difference in the increase of RP between two groups(P﹥0.05).In Jing-moxibustion group,the score of RP was higher at 1 month follow-up than that before treatment(P﹤0.05).There was no significant difference in the increase of RP at 1 month follow-up and before treatment in grain-shape moxibustion group(P﹥0.05).3.2.3 BP DimensionThe results suggested that at the end of treatment and at 1 month follow-up,both groups increased in the score of BP(P﹤0.05),and the score of Jingmoxibustion group increased more than the other group(P﹤0.05).3.2.4 GH dimensionThe results suggested that at the end of treatment,both groups increased in the score of GH(P﹤0.05).There was no significant difference in the increase of GH between two groups(P﹥0.05).In grain-shape moxibustion group,the score of GH was higher at 1 month follow-up than that before treatment(P﹤0.05).There was no significant difference in the increase of GH at 1month follow-up and before treatment in Jing-moxibustion group(P﹥0.05).3.2.5 VT dimensionThe results suggested that in Jing-moxibustion group,the score of VT was higher at the end of treatment and 1 month follow-up than that before treatment(P﹤0.05).In grain-shape moxibustion group,there was no significant difference in the increase of VT before treatment,at the end of treatment and 1 month follow-up(P﹥0.05).3.2.6 SF dimensionThe results suggested that in Jing-moxibustion group,the score of SF was higher at 1 month follow-up than that before treatment(P﹤0.05),but the score of SF was not higher at the end of treatment than that before treatment(P﹥0.05).In grain-shape moxibustion group,there was no significant difference in the increase of SF before treatment,at the end of treatment and 1 month follow-up(P﹥0.05).3.2.7 RE dimensionThe results suggested that in grain-shape moxibustion group,the score of RE was higher at the end of treatment and 1 month follow-up than that before treatment(P﹤0.05).In Jing-moxibustion group,there was no significant difference in the increase of RE before treatment,at the end of treatment and 1 month follow-up(P﹥0.05).3.2.8 MH dimensionThe results suggested that at the end of treatment,both groups increased in the score of MH(P﹤0.05).There was no significant difference in the increase of MH between two groups(P﹥0.05).In Jing-moxibustion group,the score of MH was higher at 1 month follow-up than that before treatment(P﹤0.05).There was no significant difference in the increase of MH at 1 month follow-up and before treatment in grain-shape moxibustion group(P﹥0.05).The results indicated that in Jing-moxibustion group,the score of PF,RP,BP,GH,VT,SF,MH at the end of treatment was higher than that before treatment(P﹤0.05).In grain-shape moxibustion group,the score of PF,RP,BP,GH,RE,MH at the end of treatment was higher than that before treatment(P﹤0.05).The score of PF and BP in Jing-moxibustion group increased more than the other group(P﹤0.05).There was no significant difference in the increase of RP,GH and MH scores between two groups(P﹥0.05).The results indicated that in Jing-moxibustion group,the score of PF,RP,BP,GH,VT,SF,MH at 1 month after the end of treatment was higher than that before treatment(P﹤0.05).In grain-shape moxibustion group,the score of PF,BP,GH at 1 month after the end of treatment was higher than that before treatment(P﹤0.05).The score of PF and BP in Jing-moxibustion group increased more than the other group(P﹤0.05).3.3 ValidityAt the end of treatment,the total validity was 50.00% in grain-shape moxibustion group and 81.25% in Jing-moxibustion group.The validity had statistically significant difference between two groups(P﹤0.05).At 1 month follow-up,the total validity was 30.00% in grain-shape moxibustion group and71.86% in Jing-moxibustion group.The validity had statistically significantdifference between two groups(P﹤0.05).4.Safety evaluationThere were three adverse reaction cases in this study,which were treatment-related.The degrees of all of them were mild,and the outcomes were good.Nobody quitted the research because of adverse reaction.As we all know,Jing-moxibustion and grain-shape moxibustion are safe therapy,with light adverse reactions.Conclusion1.Both Jing-moxibustion and grain-shape moxibustion therapy have curative effect of knee osteoarthritis,and the effect of Jing-moxibustion is better than grain-shape moxibustion.2.Both Jing-moxibustion and grain-shape moxibustion therapy can improve the quality of life of patients with knee osteoarthritis.The effect of Jing-moxibustion on life quality improvement is better than grain-shape moxibustion. |
PDF Full Text Request