The Clinical Research Of Modified Danzhi Xiaoyaosan On Insomnia Of Fire Derived From Stagnation Of Live

Objective:To observe the clinical curative effect of modified Danzhi Xiaoyaosan treating insomnia of fire derived from stagnation of live,and evaluate its safety.Methods: The 72 patients who met the inclusion criteria were randomly divided into experimental group and control group,each group had 36 patients.The treatment of experimental group was:danpi 10 g,chaozhizi 10 g,chaihu 10 g,chaobaizhu 15 g,baishao12g,danggui 12 g,fuling 30 g,xiangfu 10 g,shenglonggu 30 g,shengmuli 30 g,yejiaoteng15g,hehuanpi 12 g,shengmaiya 30 g.Drinking a dose of medicine everyday,blunt with200 ml of water,and divided into morning and evening two times.The treatment of control group was:shumian capsule,1.2g,bid.During the treatment,it is forbidden to take sleeping pills,prohibiting the use of all non drug therapy to treat insomnia.Patients who combine of other diseases and must take medicine,the medicine must be marked in the personal data.The duration of treatment was 4 weeks,the data from Pittsburgh sleep quality index(PSQI)and symptomatic score chart of Chinese medicine of two groups were processed with SPSS19.0 to see the difference after the treatment.The patient's discomfort was recorded in the treatment,and compare each groups,difference of blood routine,liver function,renal function,and electrocardiogram after treatment,evaluate the safety of drugs objectively.Results:1.Efficacy evaluation: 5 cases in the experimental group were cured,markedly effective is 15 cases,effective is 15 cases,ineffective is 1 cases,the total effective rate is97.22%.1 cases in the control group was cured,markedly effective is 6 cases,effective is 24 cases,ineffective is 5 cases,the total effective rate is 86.11%.After treatment,the difference between the two groups was statistically significant(P<0.05).2.Pittsburgh sleep quality index(PSQI)scale comparison:After treatment compared with before treatment,two groups have statistically significant difference(P<0.05),and the difference between the two groups after treatment have statistically significant difference(P<0.05).3.Comparison of TCM symptom score:After treatment compared with before treatment,two groups have statistically significant difference(P<0.05),and the difference between the two groups after treatment have statistically significant difference(P<0.05).4.Safety evaluation: During the course of medication,2 patients in the experimental group showed mild discomfort,and continued to take the medication.Blood routine,liver function,renal function,and electrocardiogram of two groups before and after treatment had no statistically significant difference(P>0.05).Conclusion:Modified Danzhi Xiaoyaosan and Shumian capsules both are safe and effective.Modified Danzhi Xiaoyaosan can significantly improve sleep quality and symptoms of patients,is worthy of further study and clinical use.