| ObjectiveTo observe the effects of 4 weeks point application with Foshousan prescription to fasting plasma glucose,2h postprandial blood glucose,hemorheology index,Toronto clinical scoring system(TCSS)and a concise health questionnaire(SF-36)in patients with diabetic peripheral neuropathy of phlegm-stasis blocking collateral type.We hope to provide theoretical support for the clinical treatment and nursing of this kind of patients.Method84 individuals who diagnosed with diabetic peripheral neuropathy of phlegm-stasis blocking collateral type were recruited according to the inclusion and exclusion criteria from department of endocrinology in people's hospital affiliated to Fujian University of traditional Chinese Medicine during november 2016 to december 2017.These patients were divided into the intervention group(42 cases)and the control group(42 cases)depending on the patient's ward number.Both groups were given routine treatment and nursing care.The control group was treated with Foshousan prescription(danggui,chuanxiong and baijiezi)at zusanli and fenglong at any time other than chenshi,while the intervention group was treated with Foshousan prescription(danggui,chuanxiong and baijiezi)with zusanli and fenglong only at chenshi.The patients were continuously treated for 4 weeks once a day and 2 hours per day.The hemorheology,TCSS and SF-36 of the two groups were monitored before and after intervention.The fasting blo-od glucose and 2 hour postprandial blood glucose of the two groups were observed and recorded before intervention,the 14th day and after intervention.Result1.The comparison of baselineThere was no significant difference in the general condition(age,sex,height and weight,etc),basic clinical data(medical history,medication and complication,etc)and the major effect factors of DPN(glycosylated hemoglobin,glycerin trimyristate,body mass index,diet control and exercise,etc)between groups before intervention(P>0.05).There was no significant difference in the scores of TCSS and SF-36(P>0.05).There was also no significant difference in fasting blood glucose,2 hours postprandial blood glucose and hemorheology(P>0.05).It showed that the two groups were comparable.2.The fasting plasma glucosePer Protocol:Before intervention,the 14th day and after intervention,there were significant differences in time effect and interaction effect between the two groups(P<0.05),but there was no significant difference in treatment the effect between the two groups(P>0,05).Intention-To-Treat:Before intervention,the 14th day and after intervention,there was a significant difference in the time effect between the two groups(P<0.05),but there was no significant difference in the interaction effect and the treatment effect between the two groups(P>0.05)·3.The 2 hour postprandial blood glucosePer Protocol:Before intervention,the 14th day and after intervention,there were significant differences in time effect and interaction effect between the two groups(P<0.05),but there was no significant difference in treatment the effect between the two groups(P>0.05).Intention-To-Treat:Before intervention,the 14th day and after intervention,there was a significant difference in the time effect between the two groups(P<0.05),but there was no significant difference in the interaction effect and the treatment effect between the two groups(P>0.05).4.The hemorheologyComparison between groups:The results of per protocol and intention-to-treat are consistent.plasma viscosity edge cutting rate 1,plasma viscosity edge cutting rate 50,plasma viscosity edge cutting rate 100,plasma viscosity edge cutting rate 200 and erythrocyte aggregation index between the two groups(P<0.05).There was no sign-ificant difference in plasma viscosity and erythrocyte sedimentation rate between the two groups(P>0.05).Comparison within groups:The results of per protocol and intention-to-treat are consistent.There were significant differences in hemorheology indexes between before and after intervention in the intervention group and the control group(P<0.05).5.TCSSComparison between groups:The results of per protocol and intention-to-treat are consistent.There was significant change in the sum of TCSS in the two groups after 4 weeks of the intervention(P<0.05).The score of neurological symptoms and sensory function in intervention group were significant better than that in control group(P<0.05).While there was no significant difference in the score of nerve reflex between two groups(P>0.05).Comparison within groups:The results of per protocol and intention-to-treat are consistent.There were significant differences in the score of neurological symptoms and sensory function as well as the sum of TCSS in the intervention group after 4 weeks of the intervention compare with that before intervention P<0.05).While there was no significant difference in the score of nerve reflex in intervention group(P>0.05).There were significant differences in the global sum of TCSS and the score of neurological symptoms in the control group after 4 weeks of the intervention compare with that before intervention(P<0.05).While there was no significant difference in the score of nerve reflex and sensory function in control group(P>0.05).6.SF-36Comparison between groups:The results of per protocol and intention-to-treat are consistent.A significant change in physical functioning and bodily pain between the two groups was found after 4 weeks of the intervention(P<0.05).While there was no significant difference in role-physical,vitality,social functioning,role-emotional,mental health and general health as well as health transition between two groups(P>0.05).Comparison within groups:The results of per protocol and intention-to-treat are consistent.There were significant differences in health transition,physical functioning,role-physical and bodily pain in the intervention group after the intervention compare with that before intervention(P<0.05).While the other was no significant difference in intervention group(P>0.05).The physical functioning and bodily pain were significant lower in the control group between before and after intervention(P<0.05).While the other was no significant difference in control group(P>0.05).7.Safety analysisNo adverse reactions associated with intervention were found during the study.Conclusions1.Point application can control blood sugar of DPN patients with phlegm-stasis blocking collateral type to a certain extent.2.Point application with timing make DPN patients with phlegm-stasis blocking collateral type effectively improve their hemorheology,and effectually improve their clinical symptoms by improving blood hypercoagulability in patients.3.Point application with timing can ameliorate the neurological symptoms and sensory function of DPN patients with phlegm-stasis blocking collateral type,such as limb numbness,limb pain.4.Point application with timing to some extent can improve the quality of life of DPN patients with phlegm-stasis blocking collateral type by ameliorating their unwell symptoms of numbness and pain. |
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