The Short-Term Efficacy Study Of Intravitreous Injection For The Macular Edema In Retinal Vein Obstructive

Background Retina vein occlusion is an eye disease with a high incidence.Its secondary macular edema can lead to severe visual impairment.At present,the main methods of treatment are intravitreal injection of Ranicizumab-an anti-angiogenic drug,or triamcinolone Acetonide tam-a cortical steroid drug.Because the short effect duration of RA and severe side effects of TA,both are limited in clinical application recently.Using TA and RA in combination and properly reducing TA dosage are feasible treatment methods.Objective To investigate the therapeutic effect of intravitreal injection of different drugs on retinal vein occlusion of macular edema through injection of TA,RA alone or combined injection of them,and to optimize therapeutic scheme of intravitreal injection of different drugs on retinal vein occlusion of macular edema.Methods 46 cases of ME patients(54 eyes)caused by clearly diagnosed RVO were selected from our hospital in July 2014 to March 2016.The 54 eyes were divided into three equal groups(consist of TA,RA,and TA+RA)according to different intravitreous injection,and each group included 18 eyes.Test the best corrected visual acuity(BCVA),intraocular pressure(IOP),central macular thickness(CMT)before and after treatment(including 1 week,1 month,2 months,3 months and 6 months)and analyze the data.Results After treatment(including 1 week,1 month,2 months,3 months and 6 months),the best corrected visual acuity of all three groups was better than before(P < 0.05),while the CMT of TA,RA,TA+RA at different time points had no significant difference(P > 0.05).The compare of before and after treatment in the three groups at different time were statistically significant(P < 0.05).The IOP of TA increased significantly at early stage and decreased gradually after one week.However,the IOP of RA rised slightly,and the IOP of TA+RA was not affected significantly.No significant difference was observed before and after treatment(P > 0.05).In comparison,the effect of combined use of TA and RA was not obvious,but significantly improved the persistence of drug efficacy and reduced the frequency of drug use(P < 0.05).Conclusion 1)Intravitreal injection of TA,RA and TA+RA in the treatment of RVO ME had significant effect on improving the visual acuity and reducing CMT.2)The incidence of three groups of complications was low;3)Combined treatment of TA and RA can effectively increase the persistence of drug efficacy and stabilize the therapeutic effects,and thus reduce the number of times of medication.