Clinical Research On The Correlation Between Serum Lipid Level And Breast Cancer Risk And Clinicopathological Features

Objective: To investigate the relationship between lipid levels and the occurrence of breast cancer,further research the association of breast cancer stage,axillary lymph node metastasis,hormone receptor status,molecular typing with lipid levels,and to find out the risk factors of breast cancer.Methods: A retrospective analysis of breast cancer in women who were received treatment in Department of Gastrointestinal Gland Surgery,the First Affiliated Hospital of GuangXi Medical University from January 2016 to September 2017.Clinical data,pathological stage,axillary lymph node metastasis,and immunohistochemistry were collected from 523 patients with breast cancer who met the inclusion criteria.748 women diagnosed with benign breast disease who were hospitalized in our department during the same period as the control group.Detect TC,TG,HDL-C,and LDL-C levels in all cases.Asubgroup analysis of the breast cancer case group was conducted to investigate the relationship between blood lipid levels and different pathological stages of breast cancer,axillary lymph node metastasis,hormone receptor status,and molecular typing.Data were analyzed using statistical software SPSS23.0,using independent samples t test analyzes blood lipid levels among the four groups.Result: Compared with the benign control group,the levels of serum TC and LDL-C in the breast cancer group were relatively high,and the difference was statistically significant.According to the group analysis of menstrual status,serum TC and LDL-C levels in postmenopausal breast cancer patients were higher than those in postmenopausal benign controls.For premenopausal patients,only the LDL-C level was observed to be higher in the breast cancer group than in the benign control group,and there was no significant difference in the remaining lipid index.Group of breast cancer patients further subgroup analysis: tumor staging of patients III-IV of TC,TG and LDL-C levels higher than those of 0-I stage.Similar results were observed in both groups of patients with different axillary lymph node status.The TC levels in ER(+)breast cancer patients were higher than those in ER(-)breast cancer patients,but there was no significant difference in serum lipid levels between PR positive and negative groups.Serum TC and LDL-C levels in the Luminal breast cancer,(5.13�0.71)and(3.05 � 0.72)mmol/L,respectively,were significantly higher than in the THBC and Herb-2-overexpression breast cancer,(4.96�0.67)and(2.82�0.68)mmol/L,respectively(t values 2.46 and 3.28,and P<0.05).However,therewas no statistically significant difference in serum lipid levels between PR positive and negative groups.Conclusion: Blood lipids are associated with the occurrence and development of breast cancer.There is a correlation between the level of cholesterol in blood lipids and the risk of breast cancer,and the effect is more pronounced in postmenopausal women.High TC,TG,and LDL-C levels were associated with pathological stage and axillary lymph node metastasis in breast cancer patients.High TC levels are associated with ER-positive breast cancer,and may be a risk factor for Luminal breast cancer.TG levels are related to the progression of breast cancer,but cholesterol has a greater impact on the occurrence and development of breast cancer.