The Development Of Survival Indicator Of Colorectal Cancer:A Study Based On Database

PURPOSE: the study is based on database searching,to figure out differences in the extent of attention-given by researchers among primary survival indicators,according to the difference in the number of literatures containing different survival indicators.Combined with correlation analysis between mortality rates and different range of survival rates extracted from SEER database,trying to bring in 10-years survival rate as a primary survival indicator of colorectal cancer.METHODS: Searching for literatures associated with survival rates of CRC include in MEDLINE/PubMed database,these literatures were published from 1969 to 2017.then dividing these literatures into 10 groups according to survival indicators employed in.1.To figure out differences among ten groups of data,they were examined with non-parametric Mann-Whitney test.2.To figure out the trend of changing in quantities of literatures,data were processed with Joinpoint regression program(JRP),the trend of changing in quantities of literatures would be descripted with joinpoint and APC value.3.Extracting mortality rates and survival rates data during 1983-2013 from SEER database,trend of changing in survival rate and mortality was calculated with JRP,survival and mortality rates data is also processed with correlation analysis.RESULTS: 1.Among the survival rates less than or equal to 5-year,the number of literatures associated with 1-,3-,5-year survival rate are greater than literatures associated with 2-,4-year survival rate,which were verified with M-W test,P < 0.05,the difference was statistically significant.Among the survival rates longer than 5-year,the number of literatures associated with 10-year survival rate is greater than literatures associated with 6-,7-,8-,9-year survival rate,results were verified with M-W test,P < 0.05,and the difference was statistically significant.There are not statistically significant differences in the number of literatures associated with 6-,7-,8-,9-years survival rate.2.There are not statistically significant differences in the number of literatures associated with 10-year survival rate,1-year survival rate and 3-year survival rate,P<0.05,but there is still statistically significant difference between the number of literatures associated with 10-year survival rate and 5-year survival rate,P<0.05.3.JP analysis show that,the growth speed of literatures associated with 1-year survival rate,3-year survival rate,and 5-year survival rate are decreasing,while the growth speed of literatures associated with 10-years survival rate is relatively stable.4.Mortality rate and survival rates of colorectal cancer extracted from SEER database showed that,1-,3-,5-,10-year survival rate increased monotonously,while mortality rate decreased monotonously in the past 40 years.Correlation analysis among survival rates and mortality rate showed that,all of the survival rates are negatively correlated with mortality rate,especially the 10-year survival rate have a higher correlation coefficient with mortality survival.Conclusion: 1.According to the number of literatures associated with different survival rates,researchers gave more attention to 1-,3-,5-year survival rate,which act as primary survival indicator nowadays.2.According to the trend of changing in the number of literatures,researchers started to pay attention to 10-year survival rate,which can become another primary survival indicator in the future.3.Results of correlation analysis showed that,the correlation coefficient between 10-year survival rate and mortality rate is stronger than that other survival rates.There are studies figured that decreasing in mortality rate gives the best evidence for improvement of prognosis,10-year survival rate may have more advantage than shorter survival rates in long-term prognosis evaluating.