Meta Analysis: The Effects Of Neoadjuvant Chemotherapy For 5-year Survival Rates Of The Patients With Gastric Cancer

Objective: To evaluate the effects of neoadjuvant chemotherapy for 5-year survival rates and radical resection(R0) rates of the patients with gastric cancer by META-analysis,so as to provide an evidence for surgical therapeutic schedule chosen.Material and Method:Search all of clinical randomized trials on neoadjuvant chemotherapy for gastric cancer in MEDLINE ,Cochrane Library,EMBASE,Ovid,CBM database and Google.A meta-analysis was carried out by collecting information based on inclusion and exclusion criteria from all trails'information available,and the publication bias analysis and the susceptivity analysis was also evaluated to make sure the results stable.Results:The meta-analysis included 11 trials among 1993 to2009.A total of 1850 patients were included in the analysis ,of which 911 patients were in the study group ( neoadjuvant chemotherapy plus surgery group) and 939 in the control group ( immediate surgery group).According to the Meta analysis to the information available,There was statistical significant diference in radical resection(R0) rates and 5-year survival rates between the study group and the control group,and the odds ratio(OR) was 1.49 and 0.67,with 95% confidence interval [CI], (1.16 -1.94;p=0.002) and ( 0.53 - 0.83; P= P=0.0003) , respectively。Conclusion : Compared with immediate operation, neoadjuvant chemotherapy followed by operation is in some distance related with increasing 5-year survival rates and radical resection(R0) rates of patients with gastric cancer. Due to the limited samples and the potential publication bias,the final conclusion still needs further trials to be evidenced.