Clinical Research On Moxibustion In Treating Cancer-related Fatigue

Objective To observe the clinical effect of moxibustion on the treatment of cancer due to sexual fatigue,to relieve the fatigue degree,and to affect the quality of life.Secondly,through the detection of cortisol(Cor)and adrenocorticotropic hormone(ACTH),to discuss cancer-related fatigue and the hypothalamus-pituitary-adrenal axis(HPA axis)and the relationship between moxibustion therapy cancer-related fatigue possible mechanism.Method A total of 60 CRF patients who met the group conditions were randomly divided into moxibustion treatment group and control group.The control group was treated with routine hospitalization.Moxibustion treatment group was treated with moxibustion on the basis of the control group,Sanyinjiao,Qihai,Shenshu,Guanyuan and Zusanli were selected.Qihai,Guanyuan,Shenshu point are placed in ai box with lit ai,and the box is placed above the acupoint.The other acupuncture points were fixed on the corresponding points with single-hole moxibustion box,and the aizhu was lit and put into the single hole moxibustion box.Each part of the above moxibustion is about20 min,and the above moxibustion quantity is suitable for local skin flushes without burning sensation.Once a day,6 times a week,1 week for 1 course of treatment,3courses of continuous treatment.The Chinese simplified fatigue scale(BFI-C)was used to evaluate the changes of patients before and after treatment,and to evaluate the efficacy of moxibustion therapy.KPS scale was used to evaluate the quality of life after treatment.At the same time,serum cortisol(Cor)and adrenal hormone(ACTH)were observed in the two groups before and after treatment,and the results were observed to be correlated with the results of the treatment.Finally,data collection,analysis and results are obtained.Results1.Comparison of fatigue symptoms in the two groups: before treatment of moxibustion group,the score of BFI-C was 6.92 ± 2.07,and the score was 3.53 ± 2.36 after treatment,and the difference was statistically significant before and after treatment(P<0.05).The score of BFI-C was 6.71 ± 2.18 in the control group,and6.56 ± 2.57 after treatment,with no statistically significant difference(P>0.05).The score of fatigue scale in moxibustion group was significantly changed.2.Comparison of fatigue degree between two groups: before treatment of moxibustion therapy group: mild fatigue 6 people,20%;Moderate fatigue of 16 persons,accounting for 53.33%;Severe fatigue 8,accounting for 26.67%.After treatment with moxibustion therapy group,it was scored again,and there were 4patients with no fatigue,accounting for 13.33%.Slight fatigue 14,accounting for46.67%;Moderate fatigue 9,accounting for 30%;Severe fatigue 3 people,accounting for 10%.After moxibustion treatment,the number of patients with moderate and severe fatigue decreased significantly,and the proportion was reduced from 80% to40%.Control group: mild fatigue 7 people,accounting for 23.33%;Moderate fatigue of 14,accounting for 46.67%;Severe fatigue 9,accounting for 30%.After treatment in the control group,there were no symptoms of fatigue,accounting for 3.33%.Slight fatigue 8,accounting for 26.67%;Moderate fatigue of 13 persons,accounting for43.33%;Severe fatigue 8,accounting for 26.67%.In the control group,the proportion of moderate and severe fatigue was reduced from 76.67% to 70%,and the difference was not statistically significant(P>0.05).Moxibustion treatment group improved fatigue level better than the control group.3.The two groups of plasma cortisol and promote adrenal hormone comparison:moxibustion treatment group: the patients before treatment plasma cortisol for44.06±9.31nmol/L,the treatment of patients after cortisol for 99.40±14.63nmol/L.Plasma with patients before treatment and promote adrenal hormone for102.23 ± 15.61pg/ml,promote adrenal hormone therapy patients after plasma for 55.93 ± 8.26pg/ml;Moxibustion treatment group before and after treatment and promote adrenal hormone cortisol differences were statistically significant(P<0.05).Moxibustion can improve patients cortisol levels,reduce promote adrenal hormone expression.Control group: the patients before treatment plasma cortisol for 46.58 ± 10.12nmol/L,and plasma cortisol after treatment was 48.05 ± 10.83nmol/L;Plasma CRH hormone with patients before treatment was 98.90 ± 15.29pg/ml,promote adrenal hormone therapy patients after plasma was 101.20 ± 13.51pg/ml;The control group before and after treatment and promote adrenal hormone cortisol differences had no statistical significance(P>0.05).Cure in the control group had no obvious effect on two kinds of hormone levels.4.Comparison of KPS scores in the two groups: there was no significant difference in KPS score between the two groups before treatment.After treatment of moxibustion therapy group,KPS score increased obviously,and the change before and after treatment was significant.After treatment in the control group,KPS score was not significantly altered,and the difference was insignificant.The difference of KPS score in the two groups was significant.Moxibustion treatment group improved the quality of life of patients better than the control group.Conclusion1.Acupuncture moxibustion can significantly relieve the fatigue symptoms and fatigue of patients.2.Acupuncture moxibustion can improve the quality of life of patients with cancer-related fatigue.3.Acupuncture moxibustion can elevate the level of cortisol hormone in patients with cancer-related fatigue,reduce the level of adrenal hormone,and affect the function of hypothalamic-pituitary-adrenal axis(HPA axis).