The Expression And Clinical Significance Of CA125 In Acute Coronary Syndrome

objective:Compare the difference of CA125 among the three subtypes of ACS(UA,STEMI and NSTEMI),the correlation of CA125 and hs CRP?BNP?LVEF?hs Tn I?CK-MB through the CA125 levels of acute coronary syndrome patients.Explore whether CA125 can assist hs Tn I and CK-MB in the diagnosis of ACS,and identify heart failure and the severity of heart failure in ACS.Methods: 168 cases of ACS patients were included who had underwent coronary arteriography of sichuan province people's hospital from 2015.01 to 2016.05.According to the clinical manifestations,electrocardiogram,myocardial damage markers,164 cases were divided into three subgroups: the STEMI group(total 87 cases containing 70 male and 17 female,mean age 64.84±11.94y),the NSTEMI group(total 36 cases containing 28 male and 8 female,mean age 66.06± 12.01y),the UA41 group(total 41 cases containing 24 male and 17 female,mean age 64.9±8.90y).control group 1(healthy group):total 67 cases containing 31 male and 36 female,mean age 59.31±16.51y).Control group 2(patients with chest pain but normal coronary angiography): total 33 cases containing 12 male and 21 female,mean age 59.61±11.46 y.General characteristics were recorded,such as gender,age,BMI,cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C),hypertension,diabetes,LVEF,cardiac function classification(Killip cardiac function classification),and so on.All patients were drew blood 12 ml to test the expressions of hs Tn I?CK-MB?hs CRP ?BNP and CA125.Paired observation:(1)the differences of CA125 among Control group 1,control group 2,UA group?NSTEMI group and STEMI group,the correlations of CA125 with the hs CRP?BNP?LVEF?hs Tn I?CK-MB;(2)the differences of CA125 between non-lung congestion and lung congestion groups.Results:(1)the CA125 in control group 1,control group 2,UA group,NSTEMI group and STEMI group were: 12(3.7,21.9)U/ml?11.2(1.1,27.8)U/ml?10.8(4.2,54.8)U/ml?11.55(2.8,157.4)U/ml?11.2(1.2,145.9)U/ml,respectively.And the differences of CA125 among these groups were no statistically significance.(p>0.05).(2)there were no correlations of CA125 and hs Tn I?CK-MB?hs CRP?BNP in control group 1,control group 2,UA group and NSTEMI group.In STEMI group,the CA125 showed negative correlations with LVEF,positive correlations with hs CRP and BNP,no correlation with CK-MB?hs Tn I.(3)the CA125 in control group 1,control group 2,non-lung congestion group and lung congestion group were: 12(3.7,21.9)U/ml?11.2(1.1,27.8)U/ml?11.2(1.2,157.4)U/ml?14.35(7.2,145.9)U/ml,respectively.And the differences of CA125 between lung congestion group and others were statistically significance.(p<0.05).Conlusions:(1)the differences of CA125 among UA group,NSTEMI group and STEMI group were no statistically significance,CA125 showed no correlation with CK-MB?hs Tn I,Explains that CA125 cannot assist CK-MB and hs Tn I in diagnosing ACS;(2)the differences of CA125 among UA group,NSTEMI group and STEMI group were no statistically significance,BNP increased in patients with acute myocardial infarction,indicate that CA125 may not recognize myocardial infarction with mild heart failure,but the CA125 showed negative correlations with LVEF,positive correlations with BNP,indicate that the elevated of CA125 response to moderate and severe heart failure.