A Study On Correlation Between TSH,hsCRP And Blood Lipid Profile And The Severity Of The Disease In The First-Episode MDD Patients

Objective:This article aims to investigate the relationship between Thyroid Stimulating Hormone(TSH),hypersensitive C-reactive protein(hsCRP)and serum lipid levels and severity of disease in patients with first-episode Major Depressive Disorder(MDD)? Methods:A total of 276 patients with untreated MDD were screened as subjects.Collecting general demographic data and evaluating the Hamilton Depression Scale(HAMD-17),the Hamilton Anxiety Scale(HAMA),and the Personal-Social Function Scale(PSP).The fasting venous blood of the subjects was used to determine the levels of thyroid function,hsCRP,fasting blood glucose and blood lipid profiles.Multiple linear regression models were used to analyze the correlation between TSH and hsCRP levels and HAMD,HAMA and PSP scores,Use the MINI 5.0 Chinese version of the suicide module to determine whether the patient has committed suicide.Logistic regression model was used to analyze the risk factors of suicidal behavior in patients with first-episode MDD.Spearman correlation analysis was used to investigate the correlation between the thyroid function and hsCRP levels in the first-episode MDD patients and the scores of the factors in the HAMD scale.Results:(1)Analysis of serum TSH levels and severity of symptoms in patients with first-episode MDD: 1.The TSH level of patients with first-episode MDD was significantly positively correlated with HAMD and HAMA scores(P<0.01),negatively correlated with PSP scores(P<0.05),TSH levels were significantly positively correlated with the scores of depression(r=0.286),personality or actual disintegration(r=0.393)and obsessive-compulsive symptoms(r=0.344)on the HAMD scale(P<0.01).and a negative correlation with age(P<0.01).There was a significant negative correlation between suicide risk and serum TSH and A-TG levels in female patients(both P<0.01).The suicide risk of patients aged 18-44 was positively correlated with the level of TSH and the degree of anxiety associated with them(all P<0.05);Suicide risk in patients aged 45-60 years was positively correlated with A-TG(P<0.01)and A-TPO(P<0.05)levels.3.There was a significant positive correlation between TSH level and depression score(r=0.286),personality or actual disintegration(r=0.393)and obsessive-compulsive factors(r=0.344)on the HAMD scale(P<0.001).(2)Analysis of serum hsCRP levels and severity of symptoms in patients with first-episode MDD: 1.Serum hsCRP levels in male and female first-episode MDD patients were positively correlated with HAMD scores(P<0.05),and negatively correlated with PSP scores(P<0.01).2.Serum hsCRP levels in female first-episode MDD patients were positively correlated with depression(r=0.254,P<0.01)and personality or actual disintegration scores(r=0.177,P<0.05).(3)The results of analysis of blood lipid profiles and suicidal behavior in patients with first-episode MDD showed: 1.The suicidal behavior of patients with first-episode MDD was positively correlated with serum TC level(P<0.05),and negatively correlated with HDL-C(P<0.05).After stratification of gender and age,this relationship remained.2.The age of male first-episode MDD patients was negatively correlated with suicidal behavior(P<0.05).Serum TG and LDL-C levels were negatively correlated with suicidal behavior in men and women with first-episode MDD in the 18-44 age group(P<0.05).Conclusion:(1)The severity of depressive symptoms and the degree of impairment of personal-social function in patients with first-episode MDD aggravated with elevated serum TSH levels.The risk factors for suicidal behavior in male first-episode MDD patients are age and A-TG levels.The risk factors for suicidal behavior in women with first-episode MDD were TSH and A-TG levels;The risk factors for suicidal behavior in men and women with first-episode MDD in the 18-44 age group are TSH levels and their associated anxiety symptoms.Suicide risk factors A-TG and A-TPO levels in men and women with first-episode of MDD in the 45-60 age group.(2)The higher the serum hsCRP level in patients with first-episode MDD,the more severe the condition of women with first-episode MDD,and the more serious the impairment of personal and social function in men with MDD.(3)Suicidal behaviors in patients with first-episode MDD were positively correlated with serum TC levels and negatively correlated with HDL-C levels.There was a negative correlation between suicidal behavior and age in male patients.Risk factors for suicidal behavior in patients aged 18-44 also included elevated serum TC levels,decreased levels of TG and LDL-C.