Study On The Hepatitis B Infection And Influence Factors Of ALT,AST,and GGT In The Anti-HBs Positive Population Within Jinchang Cohort

Objectives To understand hepatitis B infection in Jinchang Cohort.And to investigate the detection rates of abnormal levels of alaninetransaminase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transferase(GGT)by analyzing various demographic characteristics,dietetic behaviors and living habits,occupational exposures,and lipid metabolic indexes in the anti-HBs positive population without a history of hepatitis within Jinchang Cohort.To explore the influence factors of abnormal levels of ALT,AST,and GGT and provide the basic evidence for it?s prevention.Methods A total of 44,169 research objects with complete data were selected from the Jinchang Cohort during June 2011 to December 2013.Demographic and dietetic behavior data were collected by questionnaire.Hepatitis B virus serum markers,biochemical indicators,and related enzyme indexes were detected by laboratory serology methods.A cross-sectional study was conducted to analyze hepatitis B infection and detection rates of abnormal levels of ALT,AST,and GGT,and to identify high-risk groups in the anti-HBs positive population without a history of hepatitis.A case-control study was conducted to explore the correlated factors of ALT,AST,and GGT,and to analyze the relationship between abnormal levels of ALT,AST,GGT and lipid metabolic indexes in the anti-HBs positive population of Jinchang Cohort.Results 1.In the cohort,positive rates of HBsAg,HBeAg,HBcAb,and HBsAb were 4.66%,0.42%,15.64%,and 62.31%,respectively,and were higher among males than females except for HBsAB.There were 17 kinds of infection models of hepatitis B in the cohort.Detection rates of HbsAg,HBeAb,HBcAb positive and HBsAg,HBeAg,HbcAb positive were 3.74% and 0.41%,respectively,and the detection rates for males was higher than that for females.HBV infection rate was 28.25%,it was higher among males than females.And it peaked in the 60-69 years age group(31.63%).It was directly related to education level,while with the education level increasing,the infection rate of HBV was gradually decreased.2.In the top7 infection models of hepatitis B,detection rates of abnormal levels of ALT,AST,and GGT were 18.20%,11.14%,and 16.64%,respectively,in the cohort,and 16.20%,9.87%,and 14.86%,respectively,in the anti-HBs positive population without a history of hepatitis.Those rates were higher among females than males.Those rates were directly related to monthly average family income,while with the monthly average family income increasing,the detection rates of ALT,AST,GGT was gradually decreased.Detection rate of ALT peaked in the 30-39 years age group(20.91%),and of AST and GGT in the 50-59 years age group(10.98% and 17.67%,respectively).Detection rate of ALT was highest in the technician profession(18.23%).3.Detection rates of abnormal levels of ALT,AST,and GGT in the smoking,alcohol drinking,tea drinking,high-salt and high-oil diet groups were higher than in the control group.Detection rates of abnormal levels of AST and GGT were directly related to drinking index,with the increasing of drinking index,the detection rates were increased.Detection rate of abnormal levels of GGT was directly related to the frequency of physical exercise,and with the frequency of physical exercise increased,the detection rate was declined.Detection rates of abnormal levels of ALT and GGT were higher in the red meat over 5 catty per week and common edible pickled and smoked foods dietetic groups than the control group,and were lower in the vegetables and fruits over 5 catty per week group than control group,and were higher in the nickel,iron,and oil fumes exposure group than in the unexposed group.Detection rates of abnormal levels of ALT,AST,and GGT in the sulfur dioxide,mineral and coal powder,gasoline and diesel,and explosion smoke exposure groups were higher than in the unexposed groups.Along with the triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),body mass index(BMI),uric acid(UA)increas ing,there were higher detection rates of abnormal levels of ALT,AST,and GGT,and while with the high density lipoprotein cholesterol(HDL-C)increasing,the detection rates was gradually decreased,showing the obviously dose-response relationship.4.Multivariate analysis showed that gender,age,smoking,alcohol drinking,BMI,TG,TC,UA,and LDL-C were correlated to abnormal levels of ALT,AST,and GGT in the anti-HBs positive population within Jinchang Cohort.Risk of abnormal levels of GGT increased with alcohol drinking index.Monthly average family income was protective against abnormal levels of ALT,AST,and GGT.The risk of abnormal levels of ALT was higher in the iron and sulfur dioxide exposure group than the unexposed group.Risk of abnormal levels of ALT,AST,and GGT was directly related to lipid metabolic indexes,and showed an obvious dose-response relationship with BMI,TG,TC,LDH-C,and UA.5.Influence factors for abnormal levels of ALT,AST,and GGT different between males and females in the anti-HBs positive population within Jinchang Cohort,although lipid metabolic indexes were a common one.Abnormal levels of ALT and GGT among females were correlated with bad habits,such as smoking and alcohol drinking.The risk of abnormal levels of ALT was higher in the iron and sulfur dioxide exposure groups than the unexposed group.Conclusions 1.The infection rate of hepatitis B was lower in Jinchang Cohort.Males ages 20-39 years should be the target group for HBV prevention.The immunization of adult should be stressed in this population.2.Detection rates of abnormal levels of ALT,AST,and GGT were high in the antiHBs positive population without a history of hepatitis within Jinchang Cohort.Males should be the major target for effective prevention and control measures against abnormal levels of ALT,AST,and GGT.Detection rates of abnormal levels of ALT,AST,and GGT were related to dietetic behaviors,occupational exposures,and biochemical indicators,and pertinence measures should be undertaken specifically in this population to prevent abnormal levels of ALT,AST,and GGT.3.A dose-response relationship was observed between risk of abnormal levels of ALT,AST,and GGT and lipid metabolic indexes.Prevention of overweight and obesity,and cardio-cerebrovascular and metabolic diseases would be important for preventing and curing abnormal levels of ALT,AST,and GGT in the anti-HBs positive population without a history of hepatitis within Jinchang Cohort.4.Influence factors for abnormal levels of ALT,AST,and GGT differed between males and females in the anti-HBs positive population without a history of hepatitis within Jinchang Cohort.Smoking and alcohol drinking were important factors among males,a population that would benefit from health education regarding smoking cessation and temperance.