Diabetes And Related Indicators Of Dose-response Relationship And Interaction Research

Objectives To understand the incidence of diabetes in Jinchang cohort,and explore the relationship between different physiological indexes,metabolic indicators and the dose response relationship between liver enzymes and diabetes,and provide scientific basis for prevention and control of diabetes in this population.Methods This study was a prospective cohort study,based on the Jinchang cohort,and included 29885 workers and retirees as research subjects.The calculation of diabetes cohort two years incidence,the incidence of diabetes in different physiological indexes,metabolic indexes and liver enzyme levels;using Cox proportional hazard model analysis the risk of different physiological indexes,metabolic indexes and liver enzymes and diabetes,and to estimate the risk ratio(hazard ratio,HR)and 95% confidence interval(confidence interval,CI);and the limitation of three spline method using hierarchical analysis method(restricted cubic splines,RCS)analysis of dose-response relationship between different physiological indexes,metabolic indexes and liver enzymes and diabetes;the interaction of multiplicative interaction analysis of different physiological indexes,metabolic indexes and liver enzymes and the incidence of diabetes mellitus the.Results 1.The cumulative incidence of diabetes in the cohort was 3.81%(1139/29885).The incidence of male is 4.40%(786/17849),and the incidence of female is 2.93%(353/12036).The incidence of male is significantly higher than that of women,and there is statistical difference(P<0.05).2.The incidence of diabetes among the total population,men and women in the cohort was statistically different among different BMI,DBP and SBP groups(P<0.05),and the incidence of diabetes increased gradually with the increase of BMI,DBP and SBP.The men in the BMI or 22kg/m2,the incidence of diabetes increased significantly,the female population in BMI is more than 23kg/m2,the incidence of diabetes increased significantly.3.Men and women in the cohort of total population,population,the incidence of diabetes was statistically significant difference in TC,TG,and HDL-C group(P<0.05),and with the increase of TC and TG levels,the incidence of diabetes increased;with the increased levels of HDL-C,diabetes incidence gradually reduce.In the male population,the incidence of diabetes was statistically different among the different LDL-C groups(P<0.05),and there was no statistical difference in the female population(P>0.05).4.The incidence of diabetes among the total population,men and women in the cohort was statistically different among different ALT,AST and GGT groups(P<0.05),and the incidence of diabetes increased gradually with the increase of ALT and AST levels.With the increase of GGT level,the incidence of diabetes in men is increasing,and the incidence of diabetes in women is rising first.5.The increase of BMI,DBP and SBP will increase the risk of diabetes.In male and female population,population,BMI and DBP and the risk of diabetes showed a positive linear dose-response relationship(Poverall <0.05,Pnon-linearity >0.05);SBP and diabetes risk have a positive nonlinear dose-response relationship(Poverall <0.05,Pnon-linearity <0.05).6.The increase of TC,TG and LDL-C increases the risk of diabetes,and the increase of HDL-C will reduce the risk of diabetes.In total population,male population,TC and diabetes risk have a positive nonlinear dose-response relationship(Poverall <0.05,Pnon-linearity,<0.05)in the female population,there is a dose-response relationship between the risk of diabetes and TC(Poverall>0.05).In the total population,male and female population,TG and LDL-C were positively correlated with the risk of diabetes mellitus(Poverall <0.05,Pnon-linearity <0.05).In total population,male population,HDL-C and diabetes risk have a negative nonlinear dose-response relationship(Poverall <0.05,Pnon-linearity,<0.05)in the female population,HDL-C showed a negative linear dose-response relationship with the risk of diabetes(Poverall<0.05,Pnon-linearity>0.05).7.The increase of ALT,AST and GGT increased the risk of diabetes.In the total population,male and female population,ALT,AST and GGT were positively correlated with the risk of diabetes mellitus(Poverall <0.05,Pnon-linearity <0.05).8.In men,the interaction between TC and TG,TC and ALT,TG and ALT,ALT and GGT,ALT and DBP are positively and multiply;the synergistic effect on the risk of diabetes,they also increased the risk of diabetes are they alone are 6.71 times,20.62 times,10.23 times,6.63 and 10.29 times.In women,TC and TG and TC interact positively with DBP,ALT and GGT.They also play a synergistic role in the risk of diabetes.They also increase the risk of diabetes by 6.75 times,7.57 times and 15.93 times respectively.Conclusion 1.The incidence of diabetes in the Jinchang cohort was high,and the incidence of the male population was significantly higher than that of the women.2.BMI is a risk factor for diabetes,and there is a positive linear dose-response relationship.3.Both SBP and DBP are risk factors for the onset of diabetes and have more significant impact on women4.TC,TG and LDL-C are all risk factors for the onset of diabetes,and HDL-C is a protective factor for the onset of diabetes.5.ALT,AST and GGT are all risk factors for diabetes and are positively correlated with the risk of diabetes.6.In the male population,the interaction of TC and TG,TC and ALT,TG and ALT,ALT and GGT,ALTand DBP are all positively multiplied.In the female population,TC and TG,TC and DBP,ALT and GGT were positively multiplied by the interaction.