Effect Of Sargassum Fusiforme Seleno-Polysaccharide On Tumor Suppression And Antioxidant Enzymes Activity In The Serum Of Mice Bearing S₁₈₀

Sargassum fusiforme Phaeophyta Sargassum Sargassum,alias sea barley,antler tip,Sargassum is not only rich in nutritional value,and has significant medical function.Pharmacological research confirmed that the active substances of Sargassum fusiforme,rich in polysaccharides,including protein,these active substances in the human body metabolism process can play a positive role.Modern research has shown,Sargassum has antitumor,antioxidant,improve immunity,in addition,Sargassum also has many physiological effects of antiviral,anti coagulation,hypoglycemic and hypolipidemic etc..This topic through the establishment of mice S180 sarcoma model,effects of Sargassum fusiforme polysaccharide containing selenium on the antioxidant system of mice bearing S180,to test the antioxidant of Sargassum fusiforme polysaccharide containing selenium and antitumor ability.In vivo anti-tumor experiment results show that,Sargassum fusiforme polysaccharide containing selenium can effectively inhibit the growth of S180 sarcoma in mice.Compared with the negative group,Sargassum fusiforme polysaccharide containing selenium in each dosage group was significant,Sargassum fusiforme polysaccharide containing selenium low,middle and high dose group,the inhibition rates were 27.4%,67.8%and 63.5%;Sargassum fusiforme polysaccharide containing selenium three dose groups all had varying degrees of improvement in S180 tumor bearing small thymus index and spleen index,the organ that Sargassum fusiforme selenium immune polysaccharide on S180 tumor bearing mice has a protective effect.The body produces free radicals in the metabolic process,superoxide free radicals can cause oxidative damage to the body,damage the body’s normal physiological function and cause cancer,the body produces a series of anti oxidase system to protect the body against free radical damage.In Sargassum fusiforme polysaccharide containing seleniu,antioxidant in vivo,Sargassum fusiforme polysaccharides on S180 tumor bearing mice anti oxidase system has obvious promoting effect.In this enzyme system,SOD could promote superoxide anion into hydrogen peroxide,Sargassum fusiforme polysaccharide containing selenium can effectively promote the activity of SOD,compared with the negative group,Sargassum fusiforme polysaccharide containing selenium low,middle and high dose group,the differences were significant;CAT can promote the hydrogen peroxide into water,the vitality of Sargassum fusiforme selenium polysaccharide on CAT in vivo tumor bearing S180 mice also have stimulative effect,compared with the negative group,Sargassum fusiforme polysaccharide containing selenium in each dose group was significant;GSH is able to react with the oxygen free radicals in the presence of GSH-PX,the elimination of Sargassum fusiforme,selenium polysaccharide dose effect on the GSH content had significant difference compared with the negative control group,at the same time,Sargassum fusiforme polysaccharide containing selenium can effectively promote the activity of GSH-PX,compared with the negative group,Sargassum fusiforme polysaccharide containing selenium in each dose group was significant.Sargassum fusiforme polysaccharide containing selenium can content in MDA tumor bearing S180 mice decreased to a certain degree,compared with the negative control group,there was a significant difference in Sargassum fusiforme selenium polysaccharide high dose group.In summary,Sargassum fusiforme polysaccharide containing selenium can inhibit S180 tumor bearing mice sarcoma growth,and increase the thymus index and spleen index in mice.At the same time,Sargassum fusiforme polysaccharide containing selenium had obvious promoting effect on antioxidant system of mice bearing S180,and can reduce the content of MDA in a certain extent.Thus,Sargassum fusiforme polysaccharide containing selenium can improve immunity,enhance antioxidant activity to inhibit tumor growth.