Analysis And Research Of The Medication Regularities For The Clinical Evidence-based Treatment Of Insomnia By Professor Yang Zhimin

ObjectiveThrough the Applying the Traditional Chinese Medicine(TCM)Inheritance Support System,sort out the medical cases of Professor Yang Zhiming’s clinical treatments of the insomnia patients,analyze and explore the common Herbal medicines for the clinical treatments of insomnia,common prescriptions,and the regularities of prescription modifications;by refining the experience of medicinal uses,clinical thinking,treatment concepts,,summarize the characteristics of medicinal uses and scholastic thoughts of Professor Yang Zhiming’s treatments of insomnia.MethodBy collecting the prescriptions for a total of 1826 cases of 586 insomnia patients received by Professor Yang Zhiming in the Outpatient Department of Guangdong Provincial Hospital of Traditional Chinese Medicine from August 31st,2009 to August 31st,2014,and using the Traditional Chinese Medicine(TCM)Inheritance Support System(V2.5),a complete prescription database with "sleeplessness" as the TCM diagnosis,and the prescription data were successively entered;and such data digging methods as the entropsy-based complex system were adopted for accomplishing the medicine management for the prescription database,analysis of medicine prescriptions and the derivatives of the results for the treatment of sleeplessness so as to tap the prescriptions regularities of Professor Yang Zhiming’s treatments of insomnia and analyze the scholastic thought features for the clinical treatments of insomnia.ResultsStatistics and analysis were conducted on the prescriptions,and a total of 1826 copies of medical cases and 264 kinds of herbal medicines were collected.1.Common herbal medicinesThere were a total of herbal medicines with appearance frequencies>400,which were respectively honey-fried licorice root,rhizoma zingiberis,poria cocos,cassia twig,radix paeoniae alba,concha ostreae,raw fructus corni,processed radix aconiti lateralis,tractylodes Alba,mume Fruit,rhizoma pinellinae praeparata,condonopsis pilosula,cinnamon,paotianxiong,Chinese yam,amomum villosum,angelica and date.2.Medicine categorizationsCategorizations were conducted on a total of 264 herbal medicines,among which those medicines with more than 10 kinds of herbal medicines include:51 kinds of deficiency-nourishing medicines,29 heat-clearing medicines,22 medicines for phlegm reduction and cough and asthma reliefs,16 astringent medicines,14 sedatives andtranquilizers,14 medicines for blood-activating and stasis-resolving,14 kinds of Qi energy regulation medicines,14 kinds of hemostatics,12 digestion-promoting medicines,11 wind-dampness repelling medicines and 11 medicines for clearing damp and promoting diuresis.3.Preion compatibilityThe degree of support values was set to 600,and association rules drug combinations were used for analysis and a total of 8 groups of medicine modes,with a total of 7 kinds of herbal medicines.When the degree of support was down-regulated to 400,a total of 35 groups of medicine modes were obtained,with a total of herbal medicines.Then the value was further down-regulated to 365,a total of 51 groups of medicine modes were obtained,with a total of 15 herbal medicines.The medicine correlations were analyzed and the rational parameters were set up and entropy hierarchical clustering data analysis method was used for digging and a total of 24 pairs of medicinal core combinations,and through refining,the common medicine groups included radix paeoniae alba-cassia twig,cassia twig-rhizoma zingiberis,rhizoma zingiberis-processed-honey-fried licorice root,mume Fruit-radix paeoniae alba-raw fructus corni,tractylodes Alba-honey-fried licorice root,Pao Tian Xiong-lodestone,cinnamon-rhizoma pinellinae praeparata,agilawood-radix achyranthis bidentatae-cinnamon.4.Common prescriptionsIt was derived that the common prescriptions include Xiao Jian Zhong Decoction,Fu ZI Li Zhong Decoction,Wen Shi Ben Tun Decoction,Po Ge Jiu Xin Decoction,Dang Gui Si Ni Decoction and Decoction for Warming Meridian 等.5.Regularities of prescription modificationsThrough the entropy hierarchical clustering data analysis method,a total of 12 modified prescriptions for the treatments of sleeplessness.ConclusionProfessor Yang Zhiming’ s clinical prescriptions for the clinical determination of treatment based on differentiation of syndromes manifested the thought of Vitality Loop Body and his prescriptions regularities are summarized as follows:1.Attachment of importance to the warming and benefiting the primordial yangThe kidney is located in Xiajiao(the lower warmer manages the outlet),and it is the congenital foundation,and the root for gasification and the starting source for the circular movements,and it is where the Gate of Vitality and true fire(renal Qi,Promordial Qi and the primordial yang)inhabit,and its main function is to warm all organisms;in case of the weakness or failure of the primordial yang,then the power for the circular movement is insufficient and leads to the imbalance of the circular movements,which is manifested as insomnia.When Professor Yang Zhiming used his prescriptions,he favored such medicinal pairs of rhizoma zingiberis-prepared aconite root-honey-fried licorice root,and he usually use such prescriptions as Po Ge Jiu Xin Decoction and Wen Shi Ben Tun Decoction,etc.to warm up the primordial yang so as to preserve power for the initiation of the circular movements.2.She was good at restraining the floating yangThe Gate of Vitality and true fire inhabit in the kidney,so it is a viscus of water and fire.In the kidney,water and fire inhabit in the same space,with them embracing each other and the yin being plain and the yang dense,thus commanding the gasification of the whole body.In case the dredging of the circular movements is excessive or the restriction is insufficient,the yang vital energy floats outside,the water and fire and water are unable to embrace each other,so the true fire will float on the surface;when yang fails to enter yin,it will be manifested as insomnia.Professor Yang Zhiming favored the prescriptions of such medicinal pairs as mume fruit-radix paeoniae alba-raw fructus corni,etc.,common mume fruit decoction and Longgu Muli Decoction so as to enable to yin and yang to embrace each other and restore the circular flows of Qi.3.Regulation of the spleen and stomach Qi energySpleen and the stomach are the foundations of acquired constitution,and they are the hub for the rises and falls of the human gasification;when the spleen rises and the stomach falls,then the Qi of middle Jiao energy rotate leftward,the liver rises from the left,while the lungs falls from the right;when those that should rise will rise,while those that should fall will fall,sleeping can be peaceful;when the spleen or stomach is hurt,the central axis is imbalanced,thus causing insomnia.Professor Yang Zhiming is good t using such medicinal pairs as tractylodes Alba-honey-fried licorice root,and he commonly used such prescriptions as Xiao Jian Zhong Decoction and Fu Zi Li Zhong Decoction to regulate the mechanism of the Qi energies of the spleen and the stomach,thus enabling those that should rise to rise,and those that should fall to fall,thus resulting in peaceful sleeping.In summary,when yin and yang are at the appropriate moments and in their locations,the sleeping can be harmonized.