Clinical Study Of Modified Taohong Siwu Capsules In The Treatment Of Carotid Atherosclerosis In Cerebral Infarction

Objective:To observe the clinical effect of modified Taohong Siwu capsules in the treatment of blood stasis and phlegm in cerebral infarction and carotid atherosclerotic plaque, and use the TCM theory to explore its mechanism, in order to validate the traditional Chinese medicine in the treatment of carotid artery plaque advantage.Methods:Choice in March 2011 to February 2013 in weifang hospital see a doctor, in line with the TCM syndrome of phlegm and blood stasis resistance winding type cerebral infarction accompanied by 90 patients with carotid atherosclerotic plaques, in accordance with the doctor successively using the random number table method, were randomly divided into observation group and control group, the observation group 45 cases of patients, 45 patients with the control group. Among them, male 25 cases in observation group of patients, 20 cases, 23 cases of male, female and 22 patients with control group. Into the age group of patients, 45-75, cultural degree: 38 cases of primary school, junior high school, 46 cases, 4 cases of high school, college or above in 2 cases. Control group using aspirin enteric-coated metformin hydrochloride combined therapy with atorvastatin calcium tablet, on the basis of the observation group in the control group used flavored peach siwu capsule, 12 months for a course of treatment. After the treatment, the two groups of patients with neck vascular color ultrasound examination, evaluation of carotid intima-media thickness and plaques area, number, Crouse integral, symptoms and signs, and blood lipids, blood viscosity, blood hs- the change of CRP and laboratory indexes. All data using Excel input by SPSS17.0 statistical software system. Measurement data t test was used to mean ± standard deviation( X ±S), said the count data using ? 2 test, powerusageeffectiveness said. Measurement data comparison between groups using independent sample t test, before and after treatment in the group is for paired samples t test. : difference was statistically significant(P < 0.05).The Results:The observation group markedly effective rate of 35.6%, the total efficiency of 80.0%, the control groupmarkedly effective rate of 31.1%, the total efficiency of 73.3%, the observation group was better than that of the control group, there was significant difference between two groups(P < 0.05). Neural function defect score: after the treatment, the observation group and the control group scores were significantly reduced,but the observation group than in control group(P < 0.01), there was significant difference. Comparison of symptom of traditional Chinese medicine curative effect: the observation group of clinical symptoms and signs were improved significantly, compared with the control group, there was significant difference(P<0.05). Carotid artery ultrasound treatment showed, compared with the control group, the observation groupof carotid artery plaque size, intima-media thickness were reduced significantly(P < 0.05). Laboratory indicators: two groups after treatment of plasma lipids and hs-CRP were significantly decreased(P < 0.05),blood viscosity decreased significantly(P < 0.01). The observation group was better than that of the controlgroup, there was significant difference(P < 0.05).Conclusion : A better clinical effect of modified Taohong Siwu capsules in the treatment of blood stasis and phlegm incerebral infarction and carotid atherosclerotic plaque, and no obvious toxic side effect.