Based On Data Mining To Analyze The Clinical Efficacy For The Treatment Of Idiopathic Membranous Nephropathy By Traditional Chinese Medicine

Objectives: Using the data mining technology to analyze the clinical experience of Professor Li Mingquan in the treatment of Idiopathic Membranous Nephropathy(IMN),to explore the rule of syndromes distributionan and the regularity of medication,to preliminary evaluate the efficacy and safety of hormones and immunosuppressive agents in the treatment of IMN with traditional Chinese medicine.Provide clinical guidance for traditional Chinese medicine treatment of IMN.Methods: In this study,the data mining technology was used to collect and summarize the outpatient electronic medical record of IMN accumulated by Professor Li Mingquan in recent years.Establish Excel database including 49 patients,the 369 medical records.Using frequency analysis,cluster analysis,nonparametric analysis and other statistical analysis methods to explore the distribution of syndromes of IMN and the law of medication,to preliminary evaluate its effectiveness and safety.Results:1.Analyzing the distribution of symptoms,signs,tongue veins and syndromes of 49 patients before treatment,the results are as follows: the frequency of symptoms in more than 5% were edema,lumbago,dry mouth,insomnia,fatigue,soreness of loins,frequent urination at night,bitter taste in mouth,anorexia,diarrhea,cough,easy cold,turbid urine,nasal obstruction,spasm of muscles,skin itching,epigastric fullness,backache,expectoration,feverishness in palms and soles,aversion to cold,sore throat,tongue dark red or red,yellow and greasy fur or thin yellow,thin pulse or slippery;.As with TCM syndrome type criteria of IMN,kidney qi deficiency is the most common in the main syndromes,followed by liver kidney yin deficiency.Blood stasis is the most common in the accompany syndrome,followed by dampness-heat.2.The prescription 369 visits of 49 patients were included in the analysis,the results are as follows:(1)We got 201 Chinese herbal medicines.The total frequency was 6437 times,use frequency in the former 20 kinds of drugs which frequency is all over 100 times,which included astragalus,angelica,rosa root,rhizome,schisandra,malt,leech,scorpion,gorgon fruit,peach kernel,safflower,rhizome,coix seed,poria,cicada,silkworm,dandelion,radix saposhnikoviae,cibot.They are the core of drugs for treating IMN.Drug classification mainly includes tonic and convergence of astringent drugs,blood stasis medicine,astringent medicine antipyretic,diuresis medicine.The four properties of herbs mainly contain cold,neutral and warm.The five tastes of herbs mainly contain bitter,sweet,acrid.The meridian tropism of herbs contain liver meridian,spleen meridian,kidney meridian and stomach meridian.(2)According to the cluster analysis and the tutor experience,we found that the common drugs used medicines are 14,3 drug combination are 10.(3)The group of using hormones and immunosuppressive agents obtain 24 cases,Chinese medicine group obtain 25 cases.Compared with the traditional Chinese medicine group,it have obviously increased symptoms,such as edema,increased symptoms of fatigue.bubble urine,facial acne,dry mouth,eye dryness,halitosis,anorexia,acid regurgitation,sore throat,loose stools.And there are no significant difference between the tongue and pulse contrast;The frequency of Chinese medicine used significantly increasing is baicalin,malt,Galli,zedoary,dandelion,radix saposhnikoviae,poria,polyporus.3.The curative effect of 49 cases who were followed up for more than 2 times,which average divided into treatment group and control group,On the basis of treatment with ACEI / ARB,antihypertensive therapy,antihypertensive therapy.The experimental group was treated with the hormone and immunosuppressive agents with the traditional Chinese medicine.The control group was treated with traditional Chinese medicine.The two groups were observed for 12 months and 15 months respectively,The results are as follows:(1)Baselines of the treatment group and the control group are comparable(P>0.05).(2)Compared with the control group,the total effective rate of the test group was 75.00%,the control group was 66.67%,the total effective rate of the treatment group was better than the control group,and the complete remission rate and effective rate of the experimental group were superior to those of the control group.(3)The comparison result of urinary 24 h urine protein in the experimental group before and after treatment was statistically significant(P<0.05).(4)There was no significant difference between the two groups after quantitative treatment of urinary protein(P >0.05).(5)Two groups of TCM symptoms have a certain effect on the symptoms of Chinese medicine,the experimental group of low back pain,nocturnal enuresis,dry mouth remission rate than the control group was significantly higher,the other symptoms remission rate of two group had no significant difference.(6)The clinical observation,1 cases of ALT increased,after symptomatic treatment ALT were improved significantly,2 cases of allergy,2 cases of diarrhea,1 case of bloating,complete remission after changing prescription.Conclusions: IMN syndrome differentiation is mainly obtain kidney qi deficiency and blood stasis damp-heat syndrome.Treatment with supplement,blood stasis,heat and dampness.Drugs commonly used to make up for the deficiency,blood stasis,astringent drug qingrelishi drugs.The curative effect analysis of the symptoms and signs of the first and last visit,24 h urinary protein quantitative analysis showed that IMN treat with the traditional Chinese medicine have curative effect.At the same time we can see that data mining technology in the inheritance and development of the cause of the motherland medicine plays a very important role.