Effect Of Moxibustion On NIK?NF-?B ?VEGF In RA Patients

Objective:To observe the effects of moxibustion on the content of NF-?B-induced kinase(NIK),nuclear factor-?B(NF-?B),vascular endothelial growth factor(VEGF),tumor necrosis factor-?(TNF-?),interleukin-1?(IL-1?)expression in patients with RA;to observe the effect of moxibustion on NIK/NF-?B signaling pathway and VEGF;to explore the mechanism of moxibustion on anti-inflammatory and analgesic effects in patients with RA.Methods:46 patients with RA who accord with the criteria from Sichuan Provincial Hospital were randomized into a treatment group and a control group,with 23 patients in each group.The control group was treated with conventional western medicine,and the treatment group was supplemented with moxibustion Zusanli,Shenshu and Ashi points on the basis of conventional western medicine treatment.It was twice a week for 4 weeks as a course of treatment,two course of treatment.Before and after treatment,clinical symptoms,routine laboratory parameters,and serum levels of NIK,NF-?B,VEGF,TNF-? and IL-1? were compared in two groups of RA patients.Statistical analysis using SPSS21.0 statistical software.Results:1.Baseline results :(1)Demographics and disease-related data Baseline: baseline of gender,age,and duration of disease in both RA patients was consistent and comparable(P>0.05).(2)Baseline of clinical symptoms and laboratory indicators:baseline of clinical symptoms and laboratory indicators before treatment in both groups were consistent and comparable(P > 0.05).(3)Baseline levels of NIK,NF-?B and VEGF in serum: the baseline levels of NIK,NF-?B and VEGF in the serum of patients with RA before treatment were consistent and comparable(P>0.05).2.Effect of Moxibustion on Clinical Symptoms and Laboratory Parameters of RA Patients :(1)Intra-group comparison: The clinical symptoms of both RA patients after treatment improved(P<0.05).Laboratory indicators improved after treatment in treatment group(P<0.01);after treatment,the levels of CRP and ESR in the control group were improved(P<0.05),and the RF content was not significantly improved(P > 0.05).(2)Comparison between groups: after treatment in two groups of RA patients,the improvement of clinical symptoms in the treatment group was better than that in the control group(P<0.05);there was no significant difference between the two groups in the improvement of laboratory parameters(P>0.05).3.The effect of moxibustion on the content of NIK,NF-?B,VEGF in serum of RA patients:(1)Intra-group comparison: NIK,NF-?B,VEGF levels in serum were improved in the treatment group before and after treatment(P<0.01).NIK and VEGF levels were improved in the control group before and after treatment(P<0.05).The content of NF-?B was not significantly improved(P > 0.05).(2)Comparison between groups: The improvement of NF-?B,VEGF in the treatment group was better than that in the control group(P<0.05).There was no significant difference between the two groups in NIK(P>0.05).Conclusions:1.Moxibustion enhances the improvement of clinical symptoms of RA patients with conventional western medicine,and thus enhance the analgesic and swelling effects of conventional western medicine on RA patients.2.Moxibustion can enhance the effect of conventional western medicine on the serum levels of NF-?B and VEGF in patients with RA,so as to enhance the antiinflammatory effect of conventional western medicine on RA patients.3.Moxibustion enhances the anti-inflammatory and analgesic effects of conventional Western medicine on RA patients,which may be related to the effect of moxibustion enhancing conventional western medicine on serum NF-?B and VEGF levels in RA patients.