Research On The Effects Of VEGF?IL-1? With Rheumatoid Arthritis Patients By Moxibustion

Objective: In this study, the rheumatoid arthritis (RA) key pathological process-an important target pannus formation and the role of moxibustion, and its important regulatory factors-vascular endothelial growth factor (VEGF) as a starting point, observe moxibustion patients with RA serum vascular endothelial growth factor (VEGF) and interleukin influence-1?(IL-1?) content, explore moxibustion treatment of patients with RA mechanism.Methods:The patient from Chengdu University of Traditional Chinese Medicine Affiliated Hospital and the Provincial People's Hospital and the hospital, meet the inclusion criteria of this study 40 patients were randomly divided into treatment group and control group,20 cases in each group. The control group with methotrexate or leflunomide, a serious condition than can Bergamo, dosage prescribed medication, the treatment group with moxibustion on the basis of the control group on the "Zusanli", "Shenshu" "Gaohuangshu "" Feishu "," Ashi", twice a week for 4 weeks for a course of treatment, a total of three courses. Before and after treatment of RA patients with clinical symptoms, DAS28 scores, laboratory parameters were evaluated; measured before and after treatment in two groups of serum VEGF by enzyme-linked immunosorbent assay (ELISA), IL-1? content, and the group and the group comparison between Discussion moxibustion treatment of patients with RA mechanism.Results:1. General information Baseline Results:Two groups of gender, age, duration and other baseline consistent, comparable (P> 0.05).2. moxibustion on clinical symptoms of RA patients, DAS28 score, affect laboratory parameters:(1). Baseline Results:Clinical symptoms before the patients were treated:VAS score, morning stiffness score, tenderness index, swelling index, symptom scores and DAS28 score; laboratory parameters:ESR, SCRP, RF baseline consistent, comparable (P> 0.05).(2).Comparison within the group:After treatment the clinical symptoms were improved, (P<0.05). Moxibustion treatment group after treatment, laboratory parameters ESR, SCRP, RF, were improved (P<0.05); the control group after treatment laboratory parameters SCRP, RF improvement, (P<0.05), ESR no improvement (P>0.05).(3). Comparison between the two groups: two groups of patients after treatment, moxibustion treatment group improved tenderness index, symptom scores, laboratory tests than the control group (P<0.05).2. moxibustion on RA patients with serum VEGF, IL-1? content:(1). Two groups of patients before treatment serum VEGF, IL-1? content baseline consistent, comparable (P>0.05).(2).Comparison within the group:After treatment serum VEGF, IL-1? content were improved (P<0.05).(3).Between the two groups:two groups of patients after treatment serum VEGF, improve the value of IL-1? content were compared, it was improved (P<0.05). Tip moxibustion group of VEGF, IL-1? to improve the content than the control group.Conclusion:1. moxibustion treatment group and the control group of conventional Western medicine can reduce the serum of patients with RA VEGF, IL-1? content affect moxibustion group of VEGF, IL-1? content is more significant.2. Moxibustion treatment group and the control group of conventional Western medicine can improve symptoms in patients with RA, DSA28 score. In tenderness index, symptom score regard, moxibustion treatment group than the control group of conventional Western medicine.3. Moxibustion enhances conventional medicine for RA patients serum VEGF, IL-1? influence content, it may be one of the effective mechanisms of moxibustion treatment of RA.4. moxibustion enhances conventional medicine for RA patients serum VEGF, IL-1? influence content, it may be one of the effective mechanisms of moxibustion treatment of RA.