| Objective To investigate the clinical characteristics of cervical cancer and CIN patients and their quality of life after treatment in order to better prevent cervical cancer,reduce the progression of CIN to cervical cancer,and improve the quality of life of patients after treatment.Methods Retrospective analysis of 268 cervical cancer patients from January 1,2012 to December 31,2017 in the First Affiliated Hospital of Jinan University as a cervical cancer group,312 CIN patients as CIN group,and 260 patients with no history of cervical disease Females were born as controls.Cervical cancer and CIN group statistics of patient information: first admission date,age,height,weight,origin,mode of delivery,culture,disease pathology,treatment,contact,etc.,and through telephone follow-up,questionnaires and other methods Patients were followed up for quality of life.The cervical cancer group was assessed for quality of life using the EORTC QLQ-CX24 scale.The scores were recorded for statistical studies;the follow-up of the CIN group focused on the outcomes of pregnancy after pregnancy and pregnancy outcomes.The women in the control group counted age,height,weight,and mode of delivery.Result1.In the cervical cancer group,the rate of vaginal delivery was high,accounting for96.2%,and the rate of cesarean section was low,accounting for 3.8%;the rate of vaginal delivery was higher in the CIN group,accounting for 92.8%,and the cesarean section rate was low.7.2%.The rate of vaginal delivery was significantly higher in the two groups than in the control group.Statistical analysis was P<0.05.The difference was statistically significant,suggesting that vaginal delivery may increase the chance of cervical infection of human papillomavirus and cause cervical cancer and CIN.The occurrence of disease.2.The proportion of patients with cervical cancer with a BMI of 25 kg/m2 was 31.4%,which was significantly higher than that of women in the control group,P<0.05,and the difference was statistically significant.However,only 16.3% of patients in the CIN group had BMI >25 kg/m2.There was no significant difference between the female and the control group,and the statistical result was P>0.05.Patients with cervical cancer with a BMI of >25 kg/m2 accounted for a higher proportion,suggesting that high body mass index may increase the incidence of cervical cancer.After controlling the age factor,the same conclusion applies.3.In the study,40.3% of the patients with cervical cancer had the following elementary education,which was significantly higher than that of the control group.The statistical result was P<0.05,suggesting that the education level of cervical cancer patients was lower than that of the control group;the proportion of the primary education of CIN patients was 23.7 Percentage of patients with higher education accounted for 15.1%.Compared with the control group,the statistical result was P>0.05,suggesting that there was no significant difference in the degree of education between CIN patients and women in the control group.It suggests that the low level of education may be one of the factors that promote HPV to cause cervical cancer.4.The source distribution of cervical cancer patients in this study suggests that there are differences in medical conditions among different regions of Guangdong Province.The most obvious is that patients in eastern Guangdong accounted for 41%,second only to the Pearl River Delta region(50%).The level of health care in the eastern region is different from that in the Pearl River Delta Region,and patients tend to be treated in cities with better medical conditions.5.The five-year survival rate of cervical cancer in this study was 95.5%.Among them,the survival rate of early cervical cancer was 99.1%,and the survival rate of advanced cervical cancer was 91.7%.The earlier the staging treatment survival rate was,the higher the recurrence rate after cervical conization treatment was.Very low,only 3%,suggesting that cervical conization is better for CIN treatment.6.The decline of quality of life after treatment of cervical cancer patients is obviously related to the treatment.The quality of life of patients undergoing surgery,chemotherapy,and radiotherapy combined is the worst;the quality of life after CIN treatment is not significantly changed,and women undergoing cervical conization are naturally conceived.The rate is not significantly different from normal women.However,the premature birth rate rose to 18.3%.Conclusion This study suggests that vaginal delivery may be one of the risk factors for the development of cervical cancer and CIN.Women with existing CIN or cervical high-risk HPV infections should choose the method of delivery.Cervical cancer patients have high body mass index,low education,and pathogenesis.Older clinical characteristics;Cervical cancer quality of life decreased after treatment,but the degree of decline was significantly related to the choice of treatment and surgical methods;there was no significant change in quality of life after CIN treatment,cervical conization treatment did not significantly affect pregnancy rate,miscarriage rate Impact,but lead to increased preterm birth rate. |
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