| Objective To explore the efficacy and safety of Qingfeng Kang in the treatment of acute gouty arthritis.Methods Type of experimental design for center randomized double-blind,parallel-group study,according to the criteria of experimental admission,120 patients in the acute attack stage of gout hospitalization in the Department of metabolism and gout clinic of Qingdao University from December 2016 to December 2017 were selected as experimental subjects.They were randomly assigned to the experimental group and the control group,60 cases in each group.Inspection group therapy:arcoxia 60 mg qd,qingfengkang 250 ml bid;Control group therapy: arcoxia 60 mg qd,placebo 250 ml bid.According to the corresponding group test scheme treat for six days,and retained C reactive protein(CRP),erythrocyte sedimentation rate(ESR),IL 1 beta(IL-1 beta)and tumor necrosis factor-α(TNF-α)on first days,fourth days,and seventh days respectively.The joint pain scores(VAS score)and swelling score of the two groups were observed and compared at day 1,2,3,7.and and the gastrointestinal reaction,blood pressure fluctuation(SBP or DBP > 20 mm Hg),blood and urine routine,liver and kidney function of the two groups were evaluated before and after the test.SPSS 21.0 software was used for statistical analysis.Quantitative data were compared with T test.Qualitative data were analyzed by chi-square test.The statistical result P < 0.05 was statistically significant.Results A total of 120 patients were included in the experiment,of which 9 cases were eliminated because of the loss of visits,56 cases in the final test group and 55 cases in the control group were followed up and included in the statistical object.Compared with the control group,the IL1-beta in the experimental group was lower than the control group at day 4,7.the difference was statistically significant(t=2.29,7.10,P < 0.05),but there was no significant difference between the experimental group and the control group at the first day(t=1.90,P > 0.05).TNF-α in the experimental group was lower than the control group at day4,7.The difference was statistically significant(t=2.46,3.31,P < 0.05),and there was no significant difference between the experimental group and the control group(t=1.96,P > 0.05)on the first day of the experimental group.The ESR value of the experimental group was lower than that of the control group at day 4,7,the difference was statistically significant(t=3.09,3.41,P < 0.05),and there was no significant difference between the experimental group and the control group(t=2.05,P>0.05).The experimental group CRP was lower than the control group on fourth days and seventh days.The difference was statistically significant(t=2.42,3.24,P<0.05),and there was no significant difference between the experimental group and the control group at first days(t=0.37,P >0.05).The test group and the control group were compared with the joint pain score(VAS score),the test group were lower than the control group at day2,3,7,the difference was statistically significant(t=2.15~2.82,P < 0.05),and the VAS score of the experimental group and the control group has no significant difference(t=1.10,P > 0.05)in first days.Swollen joint scores between the experimental group and control groups,sections3,7,the difference was statistically significant(t=2.14,2.87,P<0.05),no significant difference was observed between the experimental group and the control group at 1,2 day(t=0.24,1.05,P>0.05).About the incidence of side effects of drugs of the experimental group and the control group,only one patient in the experimental group showed WBC decline.There were no significant differences in the incidence of abnormal liver function.(c2=0.17,P>0.05),and there were no obvious cases of gastrointestinal reactions(mild nausea,stomach upset),elevation of blood pressure(SBP or DBP increased≥20mm Hg),abnormal kidney function and abnormal urine test in the two groups.Conclusion The drink of Qingfengkang can improve the anti-inflammatory and analgesic effect in patients with acute gouty arthritis attacks,and has good safety. |
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