Surveillance And Analysis Of Pathogenic Bacteria In RICU

Objective: To investigate the pathogen distribution and drug resistance in the intensive care unit of Department of respiration(RICU)patients to provide reference for empirical drug use in clinic.Methods: A retrospective analysis was carried out on patients in RICU of First Affiliated Hospital of Chongqing Medical University Department of respiration from May 2015 to April 2017,and the drug resistance of cultured bacteria was analyzed.Results: A total of 559 strains nonrepetitive strains were isolated in RICU during the past two years,Including 364 strains from sputum(65.1%),78 strains(13.9%)from bronchoscopy lavage fluid,53(9.5%)strains from blood,32(5.7%)strains from urine,and 23 strains from other specimens(4.1%).Among the 559 strains pathogen collected,443 strains were gram negative bacteria,Accounting for 79.2%,and 57 strains were gram positive bacteria,Accounting for 10.2%,and 59 strains were fungi,accounting for 10.5%.The main pathogen of RICU was negative bacteria,ranked in the top five of the gram negative bacteria were Acinetobacter bauman,Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli,Stenotrophomonas maltophilia,accounting for 46.7%,15.2%,10%,5%,4.5%.Acinetobacter baumannii drug resistance is ser ious showing resistance to common drugs except tigecycline.Pseudomonas aeruginosa was sensitive to three or four generation cephalosporins,levofloxacin and gentamicin,all of which were above 50%.The extensively resistant bacterium and carbapenem resistant strains were highest in Acinetobacter bauman,accounting for the total number of Acinetobacter baumannii 61.4% and 95% Pseudomonas aeruginosa extensively drug resistant bacteria was less,but the carbapenemase producing more.The extensively drug resistant bacterium and carbapenem resistant srains of Enterobacteriaceae were less.Conclusion: The pathogen of RICU was mainly Gram-negative bacteria.Enterobacteriaceae still maintain good sensitivity to carbapenems,but Acinetobacter baumannii and Pseudomonas aeruginosa were significantly higher than the national drug resistance.should strengthen the management and control of carbapenems and reduce the use of reduced resistance.