Investigation On Multi-resistant Bacteria Infection Situation And Clinical Significance In Intensive Care Unit

Background and objective: In recent years,with the continuous development of medical technology,the application of invasive operation,all kinds of antibacterial drugs,especially the wide use of broad-spectrum antimicrobial agents,offered opportunities to bacteria infection,resistance and widespread.That caused great harm to the patient's health and life.Multi-resistant bacteria is more easily to be produced and disseminated in intensive care unit(ICU)because the patients with a critical condition,low resistance and centralized management.So it is important to investigate and analysis the changing drug resistance,production regularity,risk factors of drug-resistant bacteria to guide our treatment strategies.This study selected patients of ICU with multiple drug-resistant bacteria infection from 2012.01 to 2016.06 as the research objects,aimed to solve the following questions:(1)The investigation of the overall infection situation of multi-resistant bacteria and the infection distribution,is to guide clinical treatment.(2)Factors such as the patient's age,length of hospital stay influenced the multiple drug-resistant bacteria infection.(3)The discussion of exploring the risk factors of multiple drug-resistant bacteria infection is useful to choose sensitive antibiotics,reduce multiple drug-resistant bacteria infection rate and prevent the occurrence of nosocomial infection.That could provide the basis for the implementation of scientific and effective intervention measures.Methods: This study chose ICU patients with multiple drug-resistant bacteria infection in our hospital between January 2012 and June 2016 as the research object,investigated and collected the corresponding data,including patient's gender,age,medical condition,catheter indwelling,pathogenic bacteria,drug sensitive information.Results: 1.The composition of multidrug resistance strains was investigated.From January 2012 to June 2016,positive results were found in 3053 cases,among which 1147 were multidrug resistant bacteria,accounting for 37.57%.Among them,1127 were gram negative(G~-)bacteria,accounting for 98.26%;gram positive(G~+)bacteria 20,accounting for 1.74%;G~-bacteria were mainly Acinetobacter baumannii,and G~+ bacteria were Staphylococcus aureus(Bauman).2.The relationship between age and the distribution of multi drug resistant bacteria.The older,the rate of multi drug resistant bacteria infection was higher.The 60-74 years old group had the highest infection rate of 36.97%.3.Stay with ICU time and multidrug resistant bacteria infection.The longer hospital stay,the higher the hospital infection rate.The lowest hospital infection rate was ?10 days group(5.96%),the highest hospital infection rate was ?30 days group(71.59%).4.The source and distribution of ICU infection strains were integrated.1147 strains were isolated from clinical specimens of ICU patients,mainly from sputum culture of 1036 strains,accounting for 90.32%.Additionally,there were 62 cases of urine,20 cases of secretion culture,18 cases of blood culture,9 cases of ascites culture,7 cases of cerebrospinal fluid culture and 4 cases of pleural effusion.It can be found that the location of multi drug resistant bacteria in ICU is mainly located at the lower respiratory tract.Conclusions: 1.Multiple drug-resistant bacteria infected in ICU patients were mainly composed of acinetobacter baumannii gram-negative bacteria and infection portion concentrated mainly on the lower respiratory tract.2.Age and length of stay in intensive care unit and multi-resistant bacteria infection rates were positively correlated.