Analysis Of Pathogen Distribution And Drug Resistance In Intensive Care Unit

Objective:To investigate the pathogen distribution and drug resistance in ICU from2010 to 2011,and to provide reference for the diagnosis of bacteria1 infection and the correct selection of antibiotics for clinic.Methods: Aretrospective analysis was made for all the isolated bacteria as well as their drug resistance.Results :Of them 323 bacterial strains were isolated,including 245 strains of gram negative bacteria,57 strains of gram positive bacteria,and 21 strains of fungi.Isolation rate limited top five from high to low were 79 strains of Acinetobacter baumanni(i24.46%),62 strains of Pseudomonas ae.ruginosa(19.20%),50 strains of Klebsiella pneumoniae(15.48%),34 strains of coagulase negative staphylococcus(10.53%), and 26 strains of Escherichia coli(8.05%). A total of 29 strains that produced ESBLs were detected from 245 strains of G-, the isolating rate is 11.84%,including 17strains Klebsiella spp and12 strains Escherichia coli . The ESBLs positive rates of E.coli and K . pneumoniae were 46.15% and 34.00%.The detected rates of the metieillin-resistant S.aureus and coagulase-negative staphylococci were 55.56% and 88.24% ,respectively,there were not glycopeptides-resistant Staphylococcus ,enterococcus faecalis and enterococcus faecium to be detected.The monilia albican(12) is the main of the 21 candida,the isolating rate is 57.14%。The monilia albican is higher sensitive to various antifungal drugs and sensitive to fluconazole,voriconazole,5-fluorocytosine and amphotericin B. No fluconazole-resistant,voriconazole -resistant and amphotericin B.- resistant were detected among the 9 non-monilia albicans.Conclusion : The predominant pathogens were Acinetobacter baumannii, Pseudomonas ae.Ruginosa, Klebsiella pneumoniae,coagulase negative staphylococcus and strains of Escherichia coli,which were isolated from outpatients and emergency patients in ICU.And the isolated strains were multi drug resistant. Clinicians should use the antibiotics reasonably based on the drug susceptibility results in order to improve the cure rate and to reduce nosocomial infections and the emergence of multiple drug—resistant strains.