Effects Of α-keto Acid On Nutritional Status And The Level Of Serum Resistin In Patients Performing Continuous Ambulatory Peritoneal Dialysis

Objective: To investigate the effects of α-keto acid on Nutritional Status and the level of serum resistin in patients performing continuous ambulatory peritoneal dialysis;Methods: A total of 60 patients with end-stage renal diseases and peritoneal dialysis who were not taken α-keto from November 2016 to June 2017 were admitted.they were randomized into two groups,there were 30 cases in α-keto acid group,30 cases in No intervention group.besides,30 healthy people during the same period in our hospital were selected as the control group;The level of serum resistin and hs-CRP were detected from these samples,biochemical indicator such as albumin(Alb)、pre-albumin(PA)、Hs-CRP 、anthropometric indexes such as triceps skinfold thickness(TSF),arm muscle circumference(AMC),body mass index(BMI)and Subjective global assessment were measured from α-keto acid Intervention group and No intervention group.All the indexes above were rechecked after six months among the two groups.Results: compared with the control group,the serum levels of resistin are obviously higher from CAPD patients(P<0.05),besides,the serum level of resistin was positive correlation with hs-CRP;To compare with No intervention group,Abl,Pa were significantly increased in α-keto acid group(P< 0.05),However,the serum level of resistin 、 hs-CRP and Subjective Global Assessment(PG-SGA)are declined.the serum level of resistin was negative correlation with albumin,prealbumin,Hb(r=-0.687,r=-0.563,r=-0.271,p<0.05)and positive correlation with PG-SGA(r=0.805,p<0.05);conclusion: Resistin is not only an inflammatory marker of human body,but also has a positive correlation with hs-CRP.α-keto acid can reduce the Resistin level of peritoneal dialysis patients and improve the microinflammatory state of the body.