| Objective: To investigate whetherthe combination of mean platelet volume(MPV)and platelet distribution width(PDW)is a good biomarker of prognosis in patients with acute ST-segment elevation myocardial infarction(STEMI)undergoing percutaneous coronary intervention(PCI).Methods: we estimatedin-hospital mortality and long-term prognosis.This study enrolled 435 consecutive patients with a diagnosis of acute STEMI who underwent primary PCI within 12 hours of symptom onset from November 2011 to March 2016 in the First Affiliated Hospital of Xinjiang Medical University.Laboratory data,including PDW and MPV,were collected from medical records.Patients were categorised into group 0(n =211,48.51%),1(n=149,34.25%),or 2(n =75,17.21%)according to the sum of values defined by cut-off levels for PDW(1:>14.12%;0: ?14.12%)and MPV(1: >10.80fl;0: ?10.80fl).We assessed in-hospital mortality and major adverse cardiovascular events(MACEs)as short-term and long-term prognostic markers.Follow-up data were obtained from telephone interviews with patients or family members.Results: In multivariate logistic regression analysis,after adjusting for multiple clinical prognostic factors,membership in group1 vs.group0(OR,7.866;95% CI,1.147–53.925,P=0.036)and membership in group2 vs.group0(OR,12.734;95% CI,1.714-–.581,P=0.013)were independent predictorsofin-hospital death.When patients who died in-hospital were excluded,Kaplan-Meier curves showed a significant gradual increase in therisk of MACEs according to the sum of the group markers(1.90%,6.71%,and 12.00% of groups 0,1,and 2,P=0.002).In a multivariable Coxproportional hazards model,membership in group1 vs.group0(OR,4.818;95% CI,1.351–17.181,P=0.015)and membership in group2 vs.group0(OR,9.357;95% CI,2.450–35.736,P=0.001)were independent predictorsof MACEs.Conclusion:PDW combined with MPV could offer better prognosis in patients with acute STEMI undergoing PCI. |
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