The Effect Of Thyroid Risk Factors In Iodine Sufficient Area On Pregnancy Complications

Objective: Maternal thyroid dysfunction during pregnancy may be associated with multiple adverse outcomes.Foreign guidelines recommend screening of thyroid function indicators for high-risk thyroid diseases during pregnancy.The effects of mild thyroid abnormalities on pregnancy outcomes are not clear.The purpose of this study was to explore the risk factors of thyroid disease and the effect of thyroid abnormality on pregnancy outcome.Methods: In this study aimed at 9414 early pregnancy women,according to gestational specific diagnostic criteria for screening thyroid function,thyroid function and grouped according to whether accord with thyroid disease risk factors,the pregnancy outcome of follow-up,and the application of SPSS statistical software for analysis Results: The incidence of gestational diabetes mellitus,high-risk group,significantly higher than the rate of premature birth,abortion rate low-risk group(23.4%vs17.5%,7.1%vs4.2%,11.6%vs7.0% P<0.05).The premature delivery rate of TSH abnormal group was significantly higher than that in TSH normal group(9.9% vs 5.2%,P=0.028).The miscarriage rate in high-risk groups was significantly higher than that in the low-risk group(11.6% vs 7.7%,P=0.02).Compared with the normal group,the low-risk TSH abnormal group was significantly higher than the normal group of TSH(10% vs 3.8%,P=0.015).The incidence rate,miscarriage rate and preterm birth rate of pregnancy diabetes in normal high-risk groups were significantly higher than that of FT4 normal low-risk group(23.6% vs 17.0 P=0.000,11.5% vs 7.7% P=0.04,6.8% vs 4.3% P=0.04).The incidence of gestational diabetes,preterm birth rate and miscarriage rate of TPOAb normal high-risk group were higher than that of TPOAb normal low-risk group(24.1%vs 17.5% P1=0.000 7.2% vs 3.9% P2=0.01;11.9% vs 7.5%,P3=0.01).TSH anomaly is a risk factor for premature delivery(OR = 2.016,95%CI = 1.102-3.685).P = 0.023).Conclusion: Thyroid function screening for all pregnant women is recommended.The indicator of screening should be TSH as the first choice.