Cumulative Resting Heart Rate Exposure And Risk Of All-Cause Mortality

Objectives The relationship between cumulative exposure to resting heart rate(cum RHR)and mortality remain unclear in the general population.Methods People were selected from the ‘2006-2007 health examination records' in kailuan,And the subject(n=47311)had attended offspring cohort examination 2(2008-2009),3(2010-2011),with completed the Rest heart rate data,without a history of myocardial infraction,no history of atrial fibrillation and has not been taking beta blockers.mortality are gained through investigation of kailuan to obtain social security information system.And for an median of 5.92 years of follow up,through the kailuan social security information systerm gets the information of death.subjects were divided into four groups by cumulative resting heart rate exposure quarterback.A higher RHR was defined as?80 beats/min,and the number of visits with a higher RHR was counted.Cox proportional risk model was used to analyze the effect of cum RHR or cumulative exposure to higher resting heart rate on mortality.Results During a median of 5.92 years of follow-up,a total of 1,753 participants died.After adjusting for major traditional cardiovascular risk factors and baseline RHR,the hazard ratio for the highest versus lowest quartile of cum RHR increased the risk of death by 56%(HR value: 1.56,95%CI: 1.32-1.86),.Each 1-SD increment in cum RHR was associated with a 37%(HR: 1.20,95% CI: 1.14-1.26)increased risk of death and displayed a J-shaped relationship.Compared with no exposure,adults who had a higher RHR at all 3 study visits were associated with a 1.75-fold higher risk(95% CI: 1.35-2.27)of mortality.with a higher degree of increase at the upper distributions of cum RHR,producing a Jshaped relationship.Conclusions Cum RHR is a risk factor for mortality and is independent of other traditional cardiovascular risk factors.Cum RHR is better than baseline resting heart rate for mortality.