| Objectives In this study,glucose tolerance test was carried out in patients with hypertension,60 cases of IFG,60 cases of IGT,60 cases of IFG + IGR,60 cases of hypertension patients with normal glucose metabolism as the control group,the serum Leptin levels were detected in each group,the relationship between serum Leptin levels and blood pressure variability in patients with IGR combined with hypertension,to explore the mechanism of abnormal blood pressure variability in patients with IGR combined with hypertension,to clarify the mechanism of abnormal blood pressure variability in patients with IGR combined with hypertension andearly intervention,to prevent target organ damage in patients with IGR combined with hypertension prevention of cardiovascular and cerebrovascular events has important clinical significance.Methods Oral glucose tolerance test was carried out on hypertensive patients admitted to general medical department of Chengde medical college in 2017.the general data,routine biochemical indexes,blood pressure variability test and serum Leptin level were recorded accurately.SPSS 20.0 software was used to analyze the measurement data.the measurement data were expressed as x s,variance analysiswas used to analyze the relationship between blood pressure variability and Leptin,pearson correlation analysis was used to analyze the relationship between blood pr-essure variability and Leptin,P< 0.05 was statistically significant.Results 1 The three subgroups of abnormal glucose regulation compared with the control group,the serum leptin level was abnormal distribution.After the logarithmic conversion,the three subgroups of abnormal glucose regulation were significantly higher than those of the normal control group(P<0.01),of which 60 cases in group IFG+IGT were higher than those in the IFG group and the IGT group(P<0.05);the body weight of the four group was more than that of the control group(P<0.05).There were significant differences in the index,(P<0.05),the waist to hip ratio of group IFG was significantly higher than that of the other three groups,and the difference was significant(P<0.01);there was no significant difference in waist hip ratio between the other two subgroups and the control group.2 The three subgroups of abnormal glucose regulation were compared with the control group.There was a significant positive correlation between the systolic blood pressure variability and the blood pressure variation coefficient in each group.The difference was significant(P<0.01), the severity of impaired glucose regulation was more serious,the higher the blood pressure variability of the patients,the worse the patient controlled blood pressure stability and the effect of lowering blood pressure.Well,the target organ damage was obvious in the patients.3 In the three subgroups of impaired glucose regulation,the serum leptin levels in the IFG+IGT group were higher than those of the other two groups.The difference was significant,and the serum leptin level was positively correlated with the blood pressure variability.Conclusions 1 The level of serum leptin in patients with impaired glucose regulation and hypertension is higher,which can directly affect the effect of daily bloodpressure control,and have great influence on the damage of the large blood vesselsand the target organ damage in the long-term.2 The blood pressure variability ofpatients with impaired glucose regulation and hypertension is larger,with the incre-ase of blood glucose fluctuation,it is not good for the patient to control the bloodpressure smoothly,and the patient will increase the risk of cardiovascular events.3 Hypertension patients should take the blood pressure variability as one of the imp-ortant treatment targets,controlling the body mass index,reducing the waist and hip ratio can help to reduce the blood pressure variability,promote the patient's blood pressure to maintain the stability,effectively reduce the damage to the large blood vessels and target organs. |
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