The Correlation On Serum 25-hydroxyvitamin D Levels And Blood Pressure Variability In Patients With Essential Hypertension

Objective:To study the correlation between Serum 25-hydroxyvitamin D [25 (OH) D]levels and blood pressure variability (BPV) to provide the basis for the clinical treatment of hypertension. MethodsrThe patients (n=140)with essential hypertension were continuously chosen from the First Affiliated Hospital of Xinjiang Medical University from June 2012 to December 2012 and were divided into 25 (OH) D non-deficient group (n= 65) and 25 (OH) D deficiency group (n=75) according to serum 25 (OH) D levels which was obtained by 24h ambulatory blood pressure monitoring (24hABPM) and serum 25 (OH) D levels detecting. The blood pressure levels and BPV were compared between the two groups, and the relationship between vitamin D and BPV were analyzed. Results:The clinic systolic blood pressure (cSBP), clinic diastolic blood pressure(cDBP),24 h systolic blood pressure (24 hSBP),24 h diastolic blood pressure(24 hDBP), daytime systolic blood pressure(dSBP), daytime diastolic blood pressure(dDBP), nighttime systolic blood pressure(nSBP), nighttime diastolic blood pressure(nDBP),24 h systolic blood pressure variability (24 hSSD),24 h diastolic blood pressure variability (24 hDSD), daytime systolic blood pressure variability(dSSD), daytime diastolic blood pressure variability(dDSD), nighttime systolic blood pressure variability (nSSD) and nighttime diastolic blood pressure variability(nDSD) in Serum 25 (OH) D deficient group were all higher than those in non-deficient group with significant differences (P<0.05). Serum 25 (OH) D levels and 24 hSSD,24 hDSD,dSSD,dDSD were negatively correlated(r=0.483,-0.320,-0.437,-0.301, P<0.01). Multiple linear regression analysis showed that 25 (OH) D was the factor for 24 hSSD(P<0.01). Conclusion:The lack of 25 (OH) D may cause an increase in the BPV.