Study On The Clinical Efficacy About The Cream Prescription Treatment Of "Not Sick" Liver Depression Spleen Deficiency Syndrome

Research backgroundThe paste has always been a major consumer market in the south,with a sol id foundation in the masses,and the concept of the cream is deeply rooted in th e hearts of the people.However,the northern region has great potential for develo pment,especially in the Beijing area.In recent years,with the rise of traditional Chinese medicine,health and beauty,the improvement of people's living standar ds and the general sub-health and health needs caused by fast-paced life,which makes traditional Chinese medicine health become the mainstream appeal.The crea m square is rigorous,stable quality,well-made,easy to carry,easy to store and easy to take.It is suitable for the adjustment of sub-health condition,anti-aging a nd strengthening constitution,middle-aged and elderly people's health care and re covery period.However,the current domestic paste market chaos,lack of manage ment standard,jagged,manufacturing process,quality stability,doses of fuzzy,ad verse reactions did not pay attention to,less than other dosage form research,lac k of scientific support,and so on,can't meet the increasing demand for paste.Research purpose1.Review of researchThrough the hospital always paste prescriptions about "not ill" change the ca rd and the characteristics of the paste reagent research,interviews forming paste paste treatment for hospital "disease" to change the expert consensus,make a paste treatment "not ill" to change the basic prescription.2.Clinical researchTo complete the related curative effect evaluation of the patients with liver depression and spleen deficiency syndrome.The curative effect of the prescription of the ointment prescription with "undiagnosed" liver depression and spleen defici ency was evaluated.Research methods1.Review of research1.1 To China academy of traditional Chinese medicine xiyuan hospital from 2009 to 2014 for "not ill" to change the treatment of Chinese medicine yinpian prescription to extract information,using Epidata3.1,Microsoft Office,Excel,Inte grated Medical Case Analysis System(IMCAS),such as statistical software,to get the prescription management,classification and summary,traditional Chinese medicine(TCM)frequency analysis,etc.1.2 Through the questionnaire survey form to access the xiyuan hospital well-known traditional Chinese medicine paste experts "disease" of traditional Chinese medicine liver depression paste prescription of expert opinion poll by the spleen deficiency,and carry on discussion,expert consensus,to formulate the basic squ are.2.Clinical research2.3 A unified Cases Report Form(CRF)table was developed,and the quest ionnaire method was adopted.The tutor conducted TCM syndrome differentiation,and collected the "undiagnosed" patients with "undiagnosed" liver depression and spleen deficiency syndrome,and improved the medical records.2.4 The innovative point of this study is to explore the research of TCM sy ndrome "undiagnosed" liver depression and spleen deficiency syndrome.Using Elec tronic Data Capture System(EDC)based on open source system to manage Dat a and use R language to write code completion,use software R 3.4.3 for statisti cal analysis.Research results1.Review of researchThe paste expert investigates.To form an expert consensus,the cream prescri ption is to treat the liver depression and spleen deficiency syndrome of Chinese t raditional Chinese medicine,so as to relieve the liver,invigorate the spleen and i nvigorate the spleen,invigorate the kidney,invigorate qi and blood,relieve the a nxiety,and cultivate the spirit of the mind.Basic prescription:Radix bupleuri90g,radix paeoniae rubra90g,radix paeoniae alba90g,radix angelicae sinensis 120g,por ia cocos90g,atractylodes90g,cortex moutan90g,gardenia90g,dangshen60g,Ameri can ginseng 120g,rhizoma atractylodis150g,coix seed1500g,cooked rehmannia ro ot90g,radix rehmanniae150g,radix achyranthis bidentatae150g,a fairy spleen90g,curculigo90g,dodder90g,dried human placenta60g,fructus ligustri lucidi90,dry grass90,rhizoma anemarrhenae120g,jade bamboo150g,cortex phellodendri100g,1 otus seed150g,abliflora45g,turmeric90g,sweet90g,bitter orange90g,red jujube90 g,safflower90g,rhizoma ligustici wallichii90g,desertliving cistanche90g,salvia mi ltiorrhiza90g,zizyphus jujube kernel150g,god eight60g,mother-of-pearl300g,amo mum fruit60g,dried tangerine or orange peel100g,liquorice45g,donkey-hide gelat in90g,tortoise plastron glue90g,honey250g,sugar250g.2.Clinical research2.1 A total of 56 patients(280 patients)were collected from the tutor's "und iagnosed" liver depression and spleen deficiency syndrome.2.2 The percentage score of the score of the card was observed:the total ef fective rate of the paste was 37.50%for 1 month.The total effective rate of the cream was 75.00%for 2 months.The total effective rate of the cream was 89.29%for 3 months.The total effective rate of the ointment was 79.57%.It was found that the continuous treatment of "undiagnosed" liver depression and spleen defici ency syndrome had a better curative effect and there was almost no cure,2.3 Evaluation of symptoms of TCM symptoms:there were 0 patients with t he first diagnosis of 14 symptoms and the effective rate after 1 month.The frequ ency of the first diagnosis and the effective rate of treatment after 2 months wer e up to 6,including fecal fecal margin,low abdominal distension and pain,food intake and absence,belching,dry mouth and pharynx,and pharyngeal foreign b ody sensation.The frequency of the first diagnosis and the effective rate of treatm ent after 3 months were more than 30%,including fecal stool,low abdominal dis tension pain,eating less sodium,belching,dry mouth and pharynx,and pharynge al foreign body sensation.The frequency of the first diagnosis and the effective ra te after the end of the treatment 1 month were 5,including fecal feces,low abd ominal distension pain,belching,dry throat,and pharyngeal foreign body.lt can b e seen that liver depression and spleen deficiency is very effective in treating co nstipation,less abdominal distension,belching,dry mouth,pharynx and other sym ptoms.2.4 Determination of WHOQOL BREF-the world health organization qualit y of life scale assessment result:Treatment day 0 and 1 month in the field of p hysiology,scale total score,self total score of physical field respectively(66.52+21.42,69.61+20.28),scale score(252.52±44.56,256.70±42.33),self total score(72.32±19.74,78.77±12.39),the t value are 3.852,2.714,3.258,P values are P<0.05,the difference is statistically significant.Treatment day 0 and 2 month in the field of physiology,in the field of psychology,scale total score,self total score of physical field respectively(66.52±21.42,70.70±19.56),psychological field(57.75±9.80,59.57±9.14),scale score(252.52±44.56,260.80±39.74),self total score(72.32±19.74,80.63±11.12),the t value are 5.094,2.780,3.958,3.786,P val ue of P<0.05 is statistically Significant.Treatment day 0 and 3 month in the field of physiological,psychological field,the scale total score,self total score of ph ysical field respectively(66.52±21.42,72.39±19.05),psychological field(57.75±9.80,59.98±8.34),environment(60.73±12.48,63.41±11.54),scale score(72.32±19.74,78.77±12.39),self total score(72.32±19.74,78.77±12.39),the t value are 4.911,3.072,4.302,4.323,,P<0.05 is statistically significant.Treatment day 0 and end of a month in the field of physiological,psychological field,the scale total sc ore,self total score of physical field respectively(66.52±21.42,72.75±17.68),psy chological field(57.75±9.80,60.46±9.22),scale score(252.52±44.56,263.34±40.49),self total score(72.32±19.74,81.13±12.62),the t value were4.081,2.677,3.028,3.650,P value of P<0.05 is statistically significant.The above analysis shows that there is a statistical significance in the field of physiology,the total score of the scale and the total score of the self-evaluati on in the treatment of 1 month to the end of treatment.There was statistical signi ficance in the psychological field of the second month to the end of the treatme nt.There was no statistical significance in the social relationship between 1 month and 1 month after treatment.2.5 Safety evaluation,rare Adverse Event(AE),no Serious Adverse Event(SAE).In conclusion:1.This study formed the basic prescription of the cream square,and the cre am prescription was used to treat "undiagnosed" liver depression and spleen defic iency syndrome to relieve liver depression,invigorate spleen and invigorate qi,in vigorate the kidney,and invigorate qi and blood.2.In this study,the formulation of the ointment prescription in the treatment of "undiagnosed" liver depression and spleen deficiency syndrome can improve t he patient's quality of life.3.In this study,the formulation of the ointment prescription in the treatment of "undiagnosed" liver depression and spleen deficiency syndrome was effective,and there were few adverse reactions.