Clinical Observation On The Treatment Of Depression Of Liver Depression And Spleen Deficiency Type Based On The Theory Of Soothing The Liver And Strengthening The Spleen

Objective: Under the guidance of the theory of soothing the liver and invigorating the spleen,Jiawei Sini Powder was used to treat the mild and moderate depression of liver depression and spleen deficiency type.By observing the improvement of its clinical symptoms,and to explore the influence of liver and spleen on mild and moderate depression and the clinical effectiveness and advantages of the treatment under the guidance of the theory of soothing the liver and invigorating the spleen,and the clinical practicability of the classical formula was further verified.Methods: 80 patients with mild to moderate depression of liver depression and spleen deficiency were included in the study.They were divided into the treatment group and the control group according to the method of random number table,40 in each group.The control group was treated with sertraline hydrochloride tablets 50 mg QD,and the treatment group was treated with Jiawei Sini Powder on the basis of the control group.The treatment time of the two groups was 6 weeks.The clinical efficacy,TCM syndrome score(tcmsss),Hamilton Depression Scale(HAMD),depression Self-evaluation Scale(SDS)and safety index evaluation were observed before and after the treatment.Results: 1.There was no difference between the two groups in age,gender,disease degree and other basic data(P > 0.05),and the two groups were comparable.2.The HAMD scale scores of the two groups before treatment were compared,P > 0.05,with no statistical significance and comparability;after 6 weeks of treatment,the HAMD scale scores of the two groups before and after treatment were compared within the group,P < 0.05,with statistical significance,the HAMD scale scores of the two groups after treatment were lower than before treatment;the HAMD scale scores of the two groups after treatment were compared The difference was statistically significant(P < 0.05).3.There was no significant difference between the two groups in the SDS score before treatment(P > 0.05);after 6 weeks of treatment,the SDS scale scores of the two groups before and after treatment were compared within the group,P < 0.05,with statistical significance,the SDS scale scores of the two groups after treatment were lower than before treatment;the SDS scale scores of the two groups after treatment were compared The difference was statistically significant(P < 0.05).4.Before treatment,the TCM syndrome score of the two groups was compared between groups,P > 0.05,there was no statistical significance;after 6 weeks of treatment,the TCM syndrome score of the two groups before and after treatment was compared within the group,P < 0.05,the difference was statistically significant,the TCM syndrome score of the two groups after treatment was lower than before treatment;the TCM syndrome score of the two groups after treatment was compared between groups The difference was statistically significant(P < 0.05).5.The high-frequency symptoms of the two groups in TCM syndrome integral were depression,lack of interest,fatigue,insomnia,hypolibido,loss of appetite,abdominal distension and loose stool.There was no difference in the above-mentioned high-frequency symptoms between the two groups before treatment(P > 0.05);after treatment,there was no difference in the efficacy of depression,lack of interest and hypolibido between the two groups(P > 0.05),fatigue,weakness and loss of libido The improvement effect of the treatment group was better than that of the control group(P < 0.05).6.In the clinical efficacy comparison,the total effective rate of the treatment group was 87.17% in HAMD scale,84.61% in SDS scale and 89.74% in TCM syndrome integral effect evaluation;in the control group,76.31% in HAMD scale,71.05% in SDS scale and 78.95% in TCM syndrome integral effect evaluation;the treatment group was compared with the control group Compared with the clinical effect of the control group,the difference was statistically significant(P < 0.05).7.Detection of safety indicators: no serious adverse reactions occurred in the two groups.Conclusions: 1.Under the guidance of the theory of soothing the liver and invigorating the spleen,Jiawei Sini Powder Combined with sertraline hydrochloride tablet can effectively treat mild to moderate depression of liver depression and spleen deficiency type.It is superior to the single western medicine in clinical efficacy,TCM syndrome score,HAMD score and SDS score;2.Jiawei Sini Powder can significantly improve the symptoms of liver depression and spleen deficiency,with fewer side effects and high safety;3.This study takes liver and spleen as the starting point,the theory of soothing the liver and invigorating the spleen can be used to guide the treatment of syndrome differentiation,and the therapeutic effect is significant,which has guiding significance for clinical research and is worth popularizing.