Analysis Of Clinical Features And Prognosis Of 58 Cases With Ovarian Endometrioid Carcinoma

Objective:The clinical data and prognosis of 58 patients with ovarian endometrioid carcinoma were retrospectively analyzed to investigate the clinical features and the influencing factors of prognosis.Method:A total of 58 cases of ovarian endometrioid carcinoma treated in the Second Hospital of Jilin University from 1st January,2011 to 1st January,2016 were retrospectively analyzed.The clinical data included preoperative clinical information,surgical pathology information,postoperative chemotherapy,follow-up investigation.Kaplan-Meier curve and Log Rank test were used for univariate analysis of risk factors associated with prognosis.COX proportional hazards regression model was used for multivariate analysis to explore independent prognostic factors.P <0.05 is statistically significant.Results:1.The median age of ovarian endometrioid carcinoma patients were 50 years old.The early stage patients accounted for 84.5%(67.2% in stage I and 17.2% in stage II),and advanced stage patients accounted for 15.5%(12.1% in stage III and3.4% in stage?).It was found that 12.1% of patients in this series were with endometriosis,15.5% had synchronous endometrioid carcinoma.Most patients expressed ER,PR and a few patients expressed P53,WT-1.2.The univariate analysis showed that FIGO stage and lymphadenectomy were significant prognostic factor for OS,but there was no significant difference in DFS.For age,menopause status,times of pregnancy/abortion,invasion of bilateral ovaries,the maximum diameter of tumor,the level of CA125 and HE4 beforesurgery,histological grade,coexistence of endometriosis,coexistence of synchronous endometrioid carcinoma,whether chemotherapy,times of chemotherapy cycle,the univariate analysis showed no significant difference in OS and DFS.3.Multivariate analysis showed the FIGO stage was independent risk factor of OS and DFS for ovarian endometrioid carcinoma,and the level of HE4 before surgery was independent risk factor for DFS.Conclusion:1.Ovarian endometrioid carcinoma was mainly diagnosed at early stage.Sometimes the carcinoma could coexist with endometriosis and synchronous endometrioid carcinoma.Most of them express ER PR and a few express P53 and WT-1.2.The univariate analysis showed the FIGO stage and lymphadenectomy had statistically significant influence on prognosis.For age,menopause status,times of pregnancy/abortion,invasion of bilateral ovaries,the maximum diameter of tumor,the level of CA125 and HE4 before surgery,histological grade,coexistence of endometriosis,coexistence of synchronous endometrioid carcinoma,whether chemotherapy,times of chemotherapy cycle,it showed no significant influence on prognosis.3.Multivariate analysis showed that FIGO stage was an independent factor in the overall survival of ovarian endometrioid carcinoma.FIGO stage and HE4 before surgery were independent factors in the disease-free survival of ovarian endometrioid carcinoma.