Clinical Study On The Correlation Of Non-motor Symptoms In Parkinson's Disease

Background and Objective: Parkinson's disease(PD)is a common degenerative disease of the nervous system.It not only has motor symptoms(MS)such as limb tremor,muscle rigidity,bradykinesia and posture gait disturbance,but also has a series of non-motor symptoms(NMS).These NMS not only affect the patient's daily life,but also can aggravate MS.Furthermore,NMS may affect the patient's quality of life more than MS severely.This study performed a retrospective study of 98 PD's patients to investigate the relationship between the incidence and time of NMS.And,it has the relationship among NMS and gender,culture level,age of onset,onset side,form of onset,course of disease,severity of illness.In addition,the correlation between non-motor symptoms was included.Methods: 1 The 98 patients with PD diagnosed in a Department of a hospital were all eligible for the clinical diagnosis of PD of the MDS in 2015,and registered general data: name,gender,age,occupation,and cultural level.2 There has registered the age of onset,onset side,onset form,course of disease,occurrence time of MS and NMS in 98 patients with PD.And 98 PD's patients was assessed by UPDRS-III,Hoehn-Yahr(H-Y),NMSS,cognitive scales,anxiety and depression scales.3 The evaluation scale used the Unified Parkinson's Rating Scale III(UPDRS-III),H-Y classification,PD's non-motor assessment scale(NMSS),Mini-mental State Examination(MMSE),Montreal Cognitive Assessment(Mo CA),Hamilton Depression Rating Scale(HAMD),Hamilton Anxiety Rating Scale(HAMA).4 SPSS 22 statistical software was used for data processing and analysis:(1)the number of cases,percentage,time's distribution of the occurrence of NMS in PD patients,and the relationship between the time of occurrence of NMS and the time of occurrence of MS;(2)Make a correlation analysis between NMS and patient's clinical data.Results: 1 There were 98 cases with at least one NMS in 98 patients,accounting for 100% of the total cases.Among them,the incidence of constipation was 79.6%,the incidence of sleep disturbance was 70.4%,the incidence of depression and sexual dysfunction was 59.2%,and the incidence of the olfaction obstacle was 42.9%.2 All NMS except hallucinations can occur before MS.Olfactory disorder occurs earliest,45 years earlier than MS.3 The incidence of diplopia and pain increased with the increase of UPDRSgrading score,which was statistically significant.The incidence of anxiety decreased with the increase of the course of disease,which was statistically significant.The incidence of depression and anxiety increased with the incidence of constipation,which was statistically significant.The incidence of hallucinations,salivation and constipation increased with age,which was statistically significant.Male patients were more prone to salivation,which was statistically significant.The incidence of dysphagia and sexual dysfunction increased with the growth of the course of disease,which was statistically significant.The patient with nset of bradykinesia was more likely to have sexual dysfunction and fatigue,which was statistically significant.The incidence of RBD and sexual function decreased with MMSE score,which was statistically significant.With the increase of the UPDRS-III score and the level of education,the incidence of fatigue increased,which was statistically significant.Conclusion: 1 All PD's patients have NMS,which is multitudinous.In these NMS,constipation,sleep disorder and depression are most common.In addition to hallucinations,the remaining NMS may appear before MS.Olfactory disorder occurs earliest.2 Diplopia and pain were positively correlated with UPDRS-III score;anxiety was negative correlated with PD's course of disease;depression and anxiety were positively correlated with and constipation;hallucinations,salivation,constipation were positively correlated with age of onset;male patients were more prone to drooling;dysphagia and sexual dysfunction were positively correlated with the course of PD;PD's patients with onset of bradykinesia are more prone to sexual dysfunction and fatigue;RBD and sexual dysfunction was negatively correlated with the MMSE score.