Study On The Effect Of The Improved University Of Colorado Parkinson''s Disease Rehabilitation Training Method On Motor Symptoms And Non-Motor Symptoms

Objective: Parkinson's disease(PD)is a common irreversible neurodegenerative disease.The current treatment is still symptomatic.As the disease progresses,especially the posture gait and balance disorder become worse and worse,the risk of falling increases,and a series of complications such as fractures and lung infections occur,which seriously affect the quality of life and even life-threatening.Several studies have shown that rehabilitation can delay disease progression and improve motor symptoms and some non-motor symptoms of PD.This topic is mainly to explore the effect of the improved(United States)of Colorado University Parkinson's Disease Rehabilitation Training Method(referred to as: Improved Rehabilitation Training Method)on the motor symptoms and non-motor symptoms of PD patients.Method: From January 2017 to June 2018,45 patients with PD inpatient and outpatient department of neurology department of Dalian Friendship Hospital affiliated to Dalian Medical University,including 22 males and 23 females,aged 45-85 years,average age(70.53±7.84)were selected.The age was divided into 3 groups,15 in the rehabilitation group,15 in the slow squat group,and 15 in the control group.There was no significant difference in the medications of the three groups before training,and no drug adjustment was performed within 3 months of the experiment.The rehabilitation team under the guidance of rehabilitation teachers to carry out improved rehabilitationtraining;the slow squatting group for slow squat training;the control group did not undergo rehabilitation training.The three groups were evaluated before training,1month after training,and 3 months later,including assessment of motor symptoms,assessment of non-motor symptoms,and assessment of daily living ability.Assessment tools for motor symptoms: UPDRS Part 3(Abbreviation UPDRS-3),Berg Balance Scale(BBS)(evaluation balance function),10 Meter Walk Test(10MWT),pace,step size and "walking-standing" timing test(Time Up and Go Test,TUGT)(evaluation of walking ability),modified Asworth scale(evaluation of muscle tone);non-motor symptom assessment tool: Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(Hamilton Depression)Scale,HAMD),Pittsburgh Sleep Quality Index(PSQI);daily life ability assessment tool: Activity of Daily Living Scale(ADL),UPDRS part 1and part 2(Abbreviation UPDRS-1 and UPDRS-2)(respectively to assess the effects of non-motor symptoms and motor symptoms on the daily life of patients).Statistical analysis was performed on the data using SPSS 22.0 software.The measurement data were averaged plus or minus standard deviation.If the data was in a normal distribution,the sample T test was used for comparison within the group;the comparison between the three groups was performed by one-way ANOVA.Non-normal distribution was performed by nonparametric test P<0.05 was considered to be statistically significant.The comparison between groups was compared between groups using one-way analysis of variance.After the test was adjusted,P<0.0167 was considered statistically significant.Result:1.There was no significant difference in the evaluation of all scales between the rehabilitation group,the slow squat group and the control group before the start of training(P>0.05).The control group was given the drug for 1 month,the motor symptoms,non-motor symptoms and daily living ability scores were changed from baseline,but there was no statistical difference(P>0.05).After 3 months,their UPDRS-3,BBS,TUTG,10 MWT,pace and stride length;HAMA,HAMD and PSQI;ADL,UPDRS-2,and UPDRS-2 scores were more severe than baseline and 1 month later,and there was a statistical difference(P<0.05).There were no significant changesin the MMSE,MoCA,and modified Asworth scale scores.2.After 1 month of rehabilitation training,the rehabilitation scores,HAMA,HAMD,and daily living ability scores of all scales except the modified Asworth scale were slightly improved compared with those before training,but there was no statistical difference(P>0.05).After 3 months of training,UPDRS-3,BBS,TUTG,10 MWT,pace and step size in exercise symptom assessment;HAMA,HAMD in non-motor symptom assessment;UPDRS-1,UPDRS-2 in daily life ability assessment the score was improved compared with that before training and 1 month after training,and there was statistical difference(P<0.05).There was no significant change in ADL score,modified Asworth scale,MoCA,MMSE and PSQI scores(P>0.05).3.After one month of training in the slow squatting group,the scores of UPDRS-3,BBS,TUTG,10 MWT and pace step were improved compared with those before training(P>0.05).After 3 months,UPDRS-3,BBS,TUTG,10 MWT,pace and step improved compared with pre-training and 1 month,with significant statistical difference(P<0.05).There was no significant improvement in the modified Asworth scale,MCOA,MMSE and PSQI scores(P>0.05).4.Comparison between groups:The three groups were evaluated for exercise symptoms,non-motor symptoms,and daily living ability at 1 month.There was no statistical significance between the three groups(P>0.05).1)After 3 months,the rehabilitation group and the control group were evaluated for motor symptoms.Medium: BBS,TUTG,10 MWT,step size and pace;non-motor symptoms: HAMA,HAMD;daily living ability:UPDRS-1,UPDRS-2 score improved compared with the control group and statistically significant(P <0.0167);ADL The scores were improved compared with the control group,but there was no statistical difference(P>0.0167).The improvement of the MoCA,MMSE,PSQI and modified Ashworth grades was not obvious.2)The slow squatting group was significantly improved in terms of step size compared with the control group.Statistical differences(P<0.0167);3)In the rehabilitation group,the scores of exercise symptoms,non-motor symptoms and daily living ability were improved,but there was no significant difference(P>0.0167).Conclusion:After 1 month of training,the scores of motor symptoms,non-motor symptoms and daily living ability of the rehabilitation group were not significantly improved compared with those before training.After 3 months,the scores of motor symptoms,non-motor symptoms and daily living ability were compared with those before training and 1 month of training.Significant improvements have been made.The slow squatting group had a significant improvement in UPDRS-3,BBS,TUTG,10 MWT,step size and pace after training for 3 months.After 3 months of training,the rehabilitation group improved in the lower respiratory symptoms,non-motor symptoms,and daily ability scores,and there was no significant improvement in cognitive and sleep assessment groups.