Correlation Of Hcy Level With IMT And CAP In Patients With Essential Hypertension In Xinjiang

Objective: To investigate the relationship between homocysteine level and central arterial pressure and carotid intima-media thickness(IMT)in Xinjiang patients with essential hypertension.Methods: We made a retrospective analysis of the data of the medical history of 521 patients who were admitted into the Department of Hypertension of the First Affiliated Hospital of Xinjiang Medical University from January 2012 to December 2016.Among the patients,According to the homocysteine level patients were divided into normal homocysteine group(n=344)and hyper homocysteine group(n=177).Detection of Serum homocysteine,triacylglycerol(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),carotid IMT and Central blood pressures(CAP)includes: Central arterial systolic pressure(CSP),central arterial diastolic blood pressure(CDP),central arterial pulse pressure(CPP),enhanced pressure(AP),reflected wave enhancement index(AIx).Results: Carotid IMT was significantly increased in subjects with hyper group compared to normal group in patients(P<0.05).folic acid was significantly lower in hyper group compared to normal group i patients(P<0.05).CSP、CPP、AP、AIx were significantly higher in subjects with hyper group compared to normal group in patients(P<0.05).Pearson correlation analysis showed that homocysteine level was positively associated with carotid IMT in patients(r=0.171,P<0.001),negatively associated with folic acid in patients(r=-0.286,P< 0.001).homocysteine level was positively associated with CSP,CPP,AP,AIx(r=0.159、0.159、0.254、0.254,P<0.05).Multivariate regression analysis showed that age,homocysteine level,central arterial pulse pressure were the influencing factors of IMT in patients with essential hypertension(P < 0.05).Conclusion: high serum homocysteine level is an independent risk factor for increased carotid IMT in patients with essential hypertension in xinjiang.The increase in serum hcy level is a risk factor in the increase of central arterial systolic blood pressure,central arterial pulse pressure,Enhanced pressure and central artery reflected wave enhancement index in patients with essential hypertension(P<0.05).