Effect Of Plasma Homocysteine Level And Carotid Intima-media Thickness On Patients With Essential Hypertension

OBJECTIVE: To investigate the relationship between homocysteine levels and carotid intima-media thickness(IMT)and gender differences in patients with essential hypertension.METHODS: A total of 748 patients with essential hypertension were enrolled in the Department of Hypertension,the First Affiliated Hospital of Xinjiang Medical University from 2013 to 2017,according to the gender grouping,age grouping,and plasma homocysteine levels.Grouping.Total cholesterol,triglycerides,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and IMT levels were determined.RESULTS: There were statistically significant differences in IMT between men and women of different ages and different Hcy groups.Multivariate linear regression analysis of male group showed that F=26.339,p<0.001,indicating that the fitted equation is meaningful,age grouping,HCY,fasting blood glucose,LDL-C independent influencing factors,all positive correlation.Multiple linear regression analysis of female group showed that F=30.637,P<0.001,indicating that the fitted equation is meaningful,age,HCY group,triglyceride and folic acid are independent factors,age,HCY group,triglyceride is positive.Correlation,while folic acid is a negative correlation.Comparison of male Hcy high and low group indicators showed statistically significant differences in systolic blood pressure,triglyceride,total cholesterol,LDL-C,folic acid and IMT;high group systolic blood pressure,triglycerides,total cholesterol The levels of LDL-C and IMT were higher than those of the lower group,and folic acid was lower than the lower group.The difference between the high and low Hcy indicators in women showed differences in fasting blood glucose,triglycerides,total cholesterol,folic acid,IMT,and age.Statistically significant;fasting blood glucose,triglyceride,total cholesterol,IMT,and age indicators were higher in the high group than in the lower group,and folic acid was lower in the lower group;the Hcy index in men and women showed a statistically significant difference.The Hcy index is higher than that of women.For males,there was no significant difference in Hcy index between different age groups.There was a statistically significant difference in Hcy index among women with different age groups.The older the age,the higher the Hcy value.Conclusion: The level of homocysteine(Hcy)is an independent risk factor for the increase of carotid intima-media thickness(IMT)in patients with essential hypertension.In general,men have higher levels of homocysteine(Hcy)than women.As we age,the level of Hcy in women is on the rise.