Meta Analysis Of Risk Factors Of Ectopic Pregnancy In Chinese Women

Objective:To explore the related risk factors of female ectopic pregnancy in China,to help clinicians,public health professionals and drug management institutions to provide the best guidelines for female reproductive health.Method:The Chinese and foreign databases were retrieved systematically to collect literatures about risk factors of Chinese women's ectopic pregnancy in recent 10 years.The language is limited to Chinese and English.According to the inclusion and exclusion criteria,the literature was independently screened,evaluated and extracted.The data and data collected by Rev Man5.3 software were analyzed by meta.If the heterogeneity test results are P>0.10,I~2<50%,we can consider the specific homogeneity of the same kind of research,and take the fixed effect model to analyze the data.If the result of heterogeneity test is P<0.10 and I~2>50%,the data is analyzed by the random effect model.Results:In this study,21 papers were included,and the NOS scale was used to evaluate the quality of the literature.The scores were equal to 6 points,and 12 risk factors related to ectopic pregnancy were extracted.After the summary analysis,it is concluded that:1?pelvic surgery history combined odds ratio OR value is 5.93,95%confidence interval(95%CI)is[4.21,8.35],the difference is statistically significant(P<0.05).It shows that the history of pelvic surgery is a risk factor for the incidence of ectopic pregnancy in Chinese women.Compared with those without pelvic surgery,the risk of ectopic pregnancy is 5.93 times higher than those without pelvic surgery.2?the history of abortion combined with odds ratio OR value is4.42,95%confidence interval(95%CI)is[2.71,7.22],the difference is statistically significant(P<0.05).It shows that abortion history is the risk factor of ectopic pregnancy in Chinese women.The risk of ectopic pregnancy is 4.42 times higher than those without abortion history.3?The OR value of the history of ectopic pregnancy combined with odds ratio was 4.27,and the 95%confidence interval(95%CI)was[3.18,5.75],the result was statistically significant(P<0.05).It shows that the history of ectopic pregnancy is an independent risk factor for ectopic pregnancy in Chinese women.The risk of ectopic pregnancy is 4.27 times higher than that of those who have no history of ectopic pregnancy.4?The history of infertility and odds ratio OR were 4.24,95%confidence interval(95%CI)[3.11,5.79],the result was statistically significant(P<0.05).It shows that the history of infertility is a risk factor for the occurrence of ectopic pregnancy in Chinese women.The risk of ectopic pregnancy is 4.24 times higher than that of those who have no history of infertility.5?The ratio of pelvic infection with odds ratio OR was 3.68,and the 95%confidence interval(95%CI)was[2.90,4.68],the result was statistically significant(P<0.05).It shows that the history of pelvic infection is an independent risk factor for female ectopic pregnancy in China,and the risk of ectopic pregnancy is 3.68 times higher than that of those without pelvic inflammatory infection.6?Intrauterine device combined odds ratio OR value is 2.75,95%confidence interval(95%CI)is[2.08,3.63],the result has statistical significance(P<0.05).The intrauterine device is a risk factor for the occurrence of ectopic pregnancy in Chinese women.The risk of ectopic pregnancy is 2.75 times higher than those without IUD.7?The contraceptive pill:oral short acting contraceptive pill combined odds ratio OR value is 2.45,95%confidence interval(95%CI)is[1.59,3.77],the difference is statistically significant(P<0.05).The oral short effect contraceptive is an independent risk factor for the occurrence of ectopic pregnancy in Chinese women.The risk of ectopic pregnancy increased by 2.45 times compared with those without oral contraceptives,and the OR value of the oral emergency contraceptive combination ratio is 2.65,95%confidence interval(95%CI)for[1.51,4.86],and the difference is statistically significant.(P<0.05).It shows that the oral emergency contraceptive is an independent risk factor for ectopic pregnancy in Chinese women.The risk of ectopic pregnancy is 2.65 times higher than those who have not taken oral emergency contraceptives.8?The odds ratio of menstrual disorder combined with OR was2.02,95%,and the confidence interval(95%CI)was[1.46,2.79],the result was statistically significant(P<0.05).It shows that menstrual disorder is one of the risk factors of ectopic pregnancy in Chinese women.Compared with normal menstruation,the risk of ectopic pregnancy is2.02 times higher than that of normal menstruation.9?Smoking combined odds ratio OR value was 1.74,95%confidence interval(95%CI)was[1.40,2.18],the result was statistically significant(P<0.05).Smoking is a risk factor for the occurrence of ectopic pregnancy in Chinese women.Compared with non-smokers,the risk of ectopic pregnancy increased by 1.74 times.10?The odds ratio of married marriage was OR 0.5,95%,and the confidence interval(95%CI)was[0.40,0.62],the result was statistically significant(P<0.05).It indicates that married can be regarded as a protective factor of ectopic pregnancy.11?The ratio of OR to the cultural level(high school and above)was 0.85 and 95%confidence interval(95%CI)was[0.69,1.04],but there was no significant difference between the ectopic pregnancy group and the normal pregnancy group(P>0.05).It shows that education level(high school or above)has no effect on the incidence of ectopic pregnancy.12?The ratio of age combined with OR was-0.18,and the 95%confidence interval(95%CI)was[-3.27,1.10],Z=0.97(P=0.33),indicating that the age of the ectopic pregnancy group was smaller than the normal pregnancy,but there was no significant difference between the two groups(P>0.05).There is no correlation between age and ectopic pregnancy.Publication bias analysis:all 6 articles were found in funnel plots,which were significantly asymmetric,indicating a risk of publication bias.Conclusion:1?The history of pelvic surgery is the main risk factor for the incidence of ectopic pregnancy in Chinese women.2?Abortion history,ectopic pregnancy history,infertility history,pelvic infection history,intrauterine device,oral emergency contraceptive drugs,menstrual disorder and smoking are independent risk factors for ectopic pregnancy in Chinese women.3?Married women can be considered as a protective factor for Chinese women with ectopic pregnancy.4?Culture level and age had no effect on the incidence of ectopic pregnancy.