The Association Study Of Bone Mineral Density And Cpeptide Level In Patients With Type 2 Diabetes Mellitus

Objective:To study the relationship between bone mineral density and C peptide level in patients with type 2 diabetes mellitus.Methods:A total of 277 T2DM patients from December 2015 to March 2017 were selected in our hospital,aged between 38 and 75 years old,the BMI is between 18 and 30kg/m2,including 127 males and 150 females.According to WHO diagnostic criteria based on the T value measured by BMD,we divided the subjects into three groups,97 cases of normal bone mass(56 males and 41 females),T ?-1;126 patients in the osteopenia group(57 males and 69 females),2.5 <T<-1;54 patients in the OP group(14 males and 40 females),T?-2.5;The BMI classification standards is according to the 2013 Guidelines for the Prevention and Control of Overweight and Obese Adults in China(BMI < 18.5kg/m2 is underweight;18.5kg/m2?BMI < 24kg/m2 is normal weight;BMI?24kg/m2 is overweight;BMI?28kg/m2 is obese)every group was divided into three groups:normal weight,overweight and obesity in order to study the effect of BMI on BMD.The differences of FPG,FCP,1h CP,2hCP,HbA1c,TC,TG,LDL,HDL,age,sex,course of disease,DPN,DR,the history of smoking and drinking were compared among the three groups.SPSS software was used for statistics Analysis,P<0.05 was statistically significant,calculated BMI = body weight(kg)/ height2(m).Results:1?The incidence of T2MD with BMD abnormality in female was higher thanthat in male,especially in OP group,the difference was statistically significant(P <0.001);2?With the increase of age and course of disease,the incidence of type 2diabetic osteoporosis increased,the difference was statistically significant(P <0.001);3?With the increase of HbA1c,the bone mass decreased and the incidence of OP increased in patients with T2MD(P = 0.042);4?With the increase of BMI,the prevalence of abnormal bone mass decreased,indicating that there was a positive correlation between BMI and BMD(P=0.001);5?The lower the proportion of drinking history,the worse the bone mass,indicating that drinking may be the protective factor of BMD.people with DPN are more likely to have OP,the difference was statistically significant(P = 0.008);6?With the failure of the islet function of T2DM,the levels of serum FCP,1h CP,2hCP decreased,the risk of T2DM with BMD decreased and the risk of OP become higher,P values were(0.003,0.002,<0.001);While FPG,TC,TG,LDL,HDL,DR,the history of smoking was not statistically significant in our study(P > 0.05);7?After univariate analysis of the significant variables were adjusted by multivariate influencing factors,we come to the conclusion that the higher the age,the lower the 2hCP level,the higher the risk of OP;the higher the BMI,the lower the risk of OP.Conclusion:1?The BMD of T2DM patients was closely related to sex,BMI,the history of drinking,DPN,age,course of disease,HbA1c,the level of FCP,1h CP and 2hCP;2?The higher the age of T2DM patients,the higher the risk of OP.The higher the BMI,the lower the risk of OP,indicating that age and BMI are important influencing factors of BMD level in T2DM patients;3?The lower the level of 2hCP,the higher the risk of OP,the prevalence rate ofOP in patients with T2DM was increased with the decrease of C-peptide secretion of islet function,which indicated that the level of C-peptide was correlated with BMD,but the mechanism still needs further study;4?The incidence of type 2 diabetic osteopathy is on the rise,detection of BMD plays an important role in early diagnosis and prevention of osteopenia and OP.