| Objective Through the statistical analysis of cervical cancer screening results of women in a rural area in Dalian in 2015,the infection status,subtypes,and age distribution characteristics in the region were analyzed,which provided a theoretical basis for the prevention and treatment of cervical cancer in the region.Methods This study relied on the national major public health project-screening of women with cancer in rural areas,selecting screening items in a rural area of Dalian City,selecting a group of 35-64 years old by cluster sampling method,voluntarily participating in cervical cancer screening and signing Informed consent of rural women in the area as a screening target.Women who require screening must have basic cognitive comprehension,no history of hysterectomy,non-menstrual periods and rule out other screening contraindications.Screening method PCR genotyping of cervical secretions samples by PCR hybridization and HPV16 or HPV18 positive test results were recalled and further colposcopy,the test results were non-HPV16 / 18 type other High-risk HPV-positive patients need to be liquid-based liquid-based cytology.Thin-layer liquid-based cytology test results ?ASCUS colposcopy again.If the results of colposcopy are suspicious or abnormal,then proceed with histopathological diagnosis.Using Microsoft Access2010 to establish a database,and by the standardized training of the input double enrollment form the final database;the use of statistical software SPSS22.0 descriptive statistical analysis of all the results,for the differences between groups using the ?2 test,test level?= 0.05;Results 1.A total of 14,672 people were enrolled in this study,of whom 1376 were HPV-infected and the infection rate was 9.38%.The prevalence of high-risk,low-riskand high-low risk HPV was 8.70%(1275/14672)and 0.46 %(68/14672)and 0.23%(33/14672).2.A total of 21 HPV genotypes were detected in this screening,among which HPV16(2.13%),HPV58(1.77%)and HPV52(1.54% The subtypes with higher infection rates were HPV11(1.21%),HPV43(0.98%)and HPV6(0.86%),respectively.3.The prevalence of HPV infection in this region was mostly single infection(79.94%)and double infection(15.04%)among multiple infections,of which HPV58 infection was the most common(accounting for 24.15% of double infection %);4.HPV infection in all age groups were HPV16,HPV52 and HPV18 infection,and the prevalence of three HPV subtypes in all age groups were 35-40 years old women were the majority,were 27.42%(34/124),20.16%(25/124)and 11.29%(14/124),respectively.The total infection rate of HPV and high-risk HPV in women aged?61 was 10.78%(132/1225)and 9.80%(120/1225)respectively.5.Among women of different education levels,the highest HPV infection rate was 10.22%(516/4740)among women with primary school education and below,and the lowest was HPV infection rate 8.31%(69/830)with college degree or above.6.In all kinds of cervical lesions,HPV subtypes were mainly HPV16,HPV18,HPV58 and HPV52,the detection rates were 40.70%(186/457),18.38%(84/457),17.29%(79 / 457)and 11.82%(54/457)respectively.The HPV infection was characterized by the increase of HPV infection with the severity of cervical lesions,but no multiple infection in cervical cancer.Conclusions 1.The infection rate of HPV among women in a rural area of Dalian was 9.38%;the high-risk HPV with higher infection rate was HPV16,HPV58,and HPV52 in order;the low-risk HPV with higher infection rate was HPV43,HPV11,and HPV6.2.The characteristics of HPV infection in women in this area are dominated by a single type of high-risk HPV infection.3.High-risk HPV infections are predominant in all age groups of women in the region,and ? 61 years are the peak age of infection.4.The HPV infection rate is lower in a woman with a low level of education in a rural area in Dalian.5.The cervical lesions in women in a rural area of Dalian are mainly infected with HPV16,HPV18,HPV58,and HPV52.The HPV multi-infection rate increases with the severity of cervical lesions. |
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