| [Objective]In this study,population-based epidemiological investigations were conducted to obtain human papilloma virus(HPV)infection in 13462 cases of asymptomatic female population and analyze its subtypes and age distribution characteristics.Women in the region are at risk of contracting high-risk HPV,which provides a theoretical basis for the screening of cervical cancer and precancerous lesions in our province.It can also provide data for HPV vaccine work.[Methods]From January 2016 to December 2016,among 13462 cases ofwomen attending gynecological clinics and physical examinations at Wuxi Maternal and Child Health Hospital,the clinical data of women undergoing HPV type test and TCT test were analyzed retrospectively and telephone interviews were conducted to collect social demographic characteristics.Information on lifestyle,menstruation,birth history,contraceptive methods and sexual life history,a total of 13,462 cases.For high-risk HPV positive or TCT detection above ASC-US,colposcopy+cervical biopsy for pathological diagnosis.[Results]1.Of the 13 462 patients who were present in our hospital for examination and physical examination,2,711 were HPV-positive and 2,711 were positive.The total infection rate was 20.14%(2711/13462),among which,HR-HPV(High-risk HPV)infection.The rate of LR-HPV(Low-risk HPV)infection rate was 18.72%(2521/13462),which was 2.86%(386/13462).The detection rate of HPV was the highest in the<24-year-old group,and the difference between the groups was greater than 35 years old.Significant(P<0.05).The detection rates of the 35-45 and 45-54-year-olds were the lowest in the two groups,and there was a significant difference between the 24-year-old group and the 25-34-year-old group(P<0.05),55-64 years old.The detection rate of the group and the?65-year-old group increased again.2.14 high-risk HPV were detected in this study.Among them,the highest infection rate was HPV58,the infection rate was 13.50%(366/2711),followed by HPV16(12.95%),HPV18(11.18%)and HPV52(9.77%).There was a statistically significant differencebetween the proportion of double and triple infections and the proportion of single infections(P<0.05).3.Among 1028 TCT-positive results,689 cases of cervical histology were positive,including 203 cases of CINI,394 cases of CINII-CINIII,and 92 cases of cervical cancer.4.2793 patients with HR-HPV positive and/or TCT abnormalities(above ASCUS)underwent colposcopy+cervical biopsy.The positive detection rate of combined screening was 20.75%(2793/13462),which was higher than TCT alone(7.64).%)and HR-HPV(18.72%)test results.The HR-HPV infection rates in CIN ?-? and cervical cancer groups were as high as 89.76%and 97.94%,respectively,which was significantly higher than that in CINI group,and the difference was statistically significant(P<0.05).[Conclusion]1.The total infection rate of cervical HPV in 13462 cases is 20.14%,and the HR-HPV infection rate is 18.72%,which is consistent with the current domestic literature.From the aspect of age distribution,the HPV detection rate was highest in women under the age of 24,suggesting that there was a trend of younger age of HPV infection in the region,and the detection rate decreased with age,but the detection rate of women over 55 years old increased again.2.This study suggests that the top four HPV infection types in this region are:58,16,18,and 52.The proportion of patients with double and triple mixed infections is relatively high,with unique characteristics of subtype distribution in the region.The HPV vaccine is basically in line with the distribution of HPV subtypes in the region,and it is recommended that women with conditions be vaccinated.3.The detection of TCT combined with HR-HPV is the most effective screening for cervical lesions and cervical cancer. |
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