Analysis Of Correlate Factors To Patients With Vascular Parkinsonism

Vascular Parkinson syndrome(VP)is a secondary Parkinson syndrome on the basis of cerebral arteriosclerosis,which was first proposed by Critchley in 1929.In recent years,VP patients continue to increase,the incidence of VP continues to rise,but at present,there is no effective treatment for VP patients,still in alleviating symptoms and delaying the progress of the course of disease.Therefore,early identification of risk factors and the occurrence of VP and early effective intervention are of great significance in preventing the occurrence and development of the disease.Objective:Through the analysis and comparison of basic informational data of patients with vascular Parkinson's disease and Parkinson's disease(PD)who were enrolled in the study,the unique clinical features and influencing factors of VP were explored for the early identification of VP patients.Treatment provides clinical basis.Methods:The retrospective study method was used to select 46 VP patients and 28 PD patients who were hospitalized in the first hospital of Handan from September 2015 to December 2017.The general demographic data,past medical history,clinical symptoms,laboratory blood specimen examination results were collected,and S was applied.PSS 25 software was used to analyze the related factors of VP patients,P < 0.05 had statistical significance.Result:(1)The average age of VP patients is higher than that of patients with PD.(2)There is a statistical difference between the two groups.The education level of PD patients is significantly more than that of VP patients under primary school.(3)There were statistical differences between the two groups in the ratio of resting tremor,muscle rigidity,cognitive dysfunction,pyramidal tract sign,and olfactory dysfunction.The resting tremor and hyposmia of VP patients were lower than those of PD patients.The proportion of myotonia,cognitive impairment,and pyramidal tract sign was higher in VP patients than in PD patients.(4)There was a statistical difference in the proportion of hypertension,diabetes,hyperlipidemia and multiple lacunar infarction in basal ganglia between the two groups.The proportion of hypertension,diabetes,hyperlipidemia and multiple lacunar infarction in basal ganglia in VP patients was significantly higher than that in PD patients.(5)There was a statistical difference between the two groups of hypersensitivity C,homocysteine,and low density lipoprotein,The hypersensitivity C,homocysteine,and low density lipoprotein in VP patients were significantly higher than those in PD patients.Conclusion:(1)Compared with patients with PD,patients with VP were more likely to have muscle rigidity,cognitive dysfunction,pyramidal tract sign,and PD patients had more tremors and olfactory disorders than VP.(2)Age,hypertension,multiple lacunar infarction in the basal ganglia,and homocysteine are independent risk factors for VP production.