The Combination Of Plasma Inflammation Factors Of The Patients With Parkinson's Disease And Vascular Parkinsonism

Objective: To investigate the association of serum IL-6 and IL-32 with Parkinson's patients(PD)and Vascular Parkinsonism(VP).Methods: A cross-sectional study was performed.64 cases PD,48 cases VP and 60 cases control group in First Affiliated Hospital of Henan University of Science and Technology were enrolled.The motor status,non-motor symptoms,disease severity,and cognitive declines of the patients were assessed by the Non-motor symptoms scale(NMSS),Mini-Mental State Examination(MMSE),the modified Hoehn and Yahr staging scale(Hoehn-Yahr),and the unified Parkinson's disease rating scale part III(UPDRSIII).Serum IL-6 and IL-32 of PD,VP and control group was detected using enzyme linked immunosorbent assay.SPSS 21.0 software was used to analyze the correlation between the two inflammatory factors and the scale scores of PD and VP,P<0.05 was statistically significant.Results:1.Onset age of the VP was greater than that of PD(F=32.452,P=0.000),The levodopa dosage in patients with VP was higher than that in patients with Parkinson's disease(t=2.792,P=0.006).Compared with PD,patients with VP were more prone to mental damage(t=2.920,P=0.004).2.The level of IL-6 in PD was significantly higher than that in patients with VP(P=0.005),IL-6 of PD and VP was higher than Control group(P=0.000),The level of IL-32 of VP was higher than PD(P=0.000),and both IL-32 of PD and VP was higher than Control group(P=0.000).3.The course of PD was positively correlated with motor symptom score and levodopa dose.4.The duration of VP is positively correlated with the motor grade and intelligence status.5.The plasma levels of IL-32 was positive correlation with NMSS in PD(r=0.690,P=0.000).6.The plasma levels of IL-32 was positive correlation with the the UPDRSIII(r=0.511,P=0.000)and Hoehn-Yahr(r=0.602,P=0.000)in VP.Conclusions:1.Two groups of patients with IL-6 and IL-32 were significantly higher than the control group.2.IL-6 was not associated with clinical symptoms in patients with PD and VP,and there was a significant positive correlation between IL-32 and non-motor symptoms of patients with PD and motor symptoms of patients with VP.