Studies Of Correlate Factors Of Patients With Vascular Parkinsonism

Objective: In 1929 ,Critchley described the concept of Vascular Parkinson(VP) firstly.In recent decades, with the development of medical imaging technology, in particular, the clinical and pathological results of VP,showed that VP is a separate syndrome.As the global population ageing, the incidence rate of VP is rising.There was no effective treatment to stop or reverse degeneration of VP,only relieving symptoms and delaying the process.Therefore,as soon as possible to forecast the occurrence of VP and intervene these patients earlier, it is very meaningful.Recently,there are few study in the side of risk factors which result in VP in home and abroad. Based on the follow-up study of patients with first cerebral infarction, the purpose of this study was to inquiry into the correlate factors which result in VP, provide a clinical basis for VP,s diagnosis in earlier period.Method:(1)Data was prospectively collected from 425 patients with first ischemic stroke in the First Affiliated Hospital of Dalian Medical University from January 1, 2002 to December 31, 2003.(2)The cases were followed up in 4 years since the first event. Record the numbers of cases which occur to VP or died of VP.Record whether the doctor's orders for compliance.(3) According to the type standard OCSP, 404 patients collected were divided into four groups:â‘ LACI;â‘¡TACI;â‘¢PACI;â‘£POCI . Record the numbers of cases which occur to VP or died of VP in each group.(4)Record the contents of following research factors: age,sex,hypertension,diabetes,heartdisease,smoking history,hemorheology(hematocrit, blood viscosity,blood plasma viscosity,fibrinogen,ESR equation K value) in first 72 hours of disease.(5)The relevant datas for calculation of the exact probability. Comparing the differences between the two groups with X2 test, P <0.05 is a statistical significance. Logistic regression model were used to calculate which factors result in VP .Result:(1)After followed up in 4 years,there were 54 patients occur to VP in 404 patients with first cerebral infarction,incidence rate is 13.4% .(2)404 patients with first cerebral infarction were investigated , according to the type standard OCSP divided into four groups:â‘ TACI:30 patients;â‘¡PACI:135 patients;â‘¢LACI: 206 patients ;â‘£POCI:33 patients .42 patients had VP in lacunar infarction group , the incidence was significantly higher than the other three groups, there were significant differences (P <0.05).(3)The main risk factors which result in VP with statistical significanceinclude:age(P=0.043,OR=1.135,95%CI=1.010-1.275);hypertensionhistory(P=0.032,OR=2.019,95%CI=1.247-4.746);bloodviscosity(P=0.041,OR=1.724,95%CI=1.036-3.058);FIB(P=0.0095,OR=2.241,95%CI=1.272-5.473).Conclusion:(1)Lacunar infarction easily lead to the occurrence of VP.(2)Age, hypertension history, blood viscosity and fibrinogen are risk factors of VP.