The Research On How The Severity Of Lesions Is Correlated To The Serum Estradiol And Testosterone Level Of The Early-stage Knee Osteoarthritis Patients

BACKGROUND Knee osteoarthritis(KOA)is a common motor system disease whose pathogenesis remains unclear,and methods of early-stage diagnosis are yet rare.Nevertheless,according to the epidemiological study,it is found that KOA is commonly occurring in the population over the age of 40,among which the morbidity for the female goes higher than that for the male of the same age,especially for those postmenopausal ones.The particular distribution over the age and gender suggests that there exists some close correlation between the KOA pathogenesis and sex hormone levels.OBJECTIVE To find out the correlation between sex hormone levels,that of the postmenopausal females and males of the same age,and the KOA severity by analyzing the early-stage KOA patients.METHODS We collected 44 patients,those admitted to the First Affiliated Hospital of Guangxi Medical University and Ninth Affiliated Hospital of Guangxi Medical University from September 2015 to November 2016,and 33 health people,as samples.They were divided into two groups by gender,which were group of postmenopausal females(n=37)and group of males of the same age(n=36).Each group was further subdivided,by K-L grading system,into subgroups of K-L 0,K-L?and K-L?.The serum estradiol and testosterone levels of each subgroup was detected with the electrochemical luminescence method,and associated respectively with K-L grade.RESULTS Within the group of postmenopausal female patients,no significant difference in serum estradiol level from K-L 0 to K-L?(P>0.05)was observed but from K-L 0 to K-L?and K-L?to K-L?(P<0.05).There was neither big difference in serum testosterone level through K-L 0,K-L?and K-L?grade in pairwise comparisons;The KOA severity showed apparent negative correlation with the serum estradiol level(r_s=-0.709,P<0.05)but no correlation with the serum testosterone(P>0.05).Within the group of male patients,no significant difference in both serum estradiol and testosterone level from K-L 0 to K-L?(P>0.05)was observed but from K-L 0 to K-L?and K-L?to K-L?(P<0.05).The serum estradiol and testosterone levels in the group of postmenopausal females were relatively lower than those in the group of males(P<0.05);The KOA severity showed apparent negative correlation with both the serum estradiol level(r_s=-0.476,P<0.05)and the serum testosterone(r_s=-0.418,P<0.05).CONCLUSION The severity of early-stage KOA shows a negative correlation with the serum estradiol level for the postmenopausal female patients and a negative correlation with the serum estradiol and testosterone levels for the males of the same age.