Clinical Study On The Treatment Of Severe Alopecia Areata With Shaoyao Gancao Granules

Literature review:This review summarizes the recent research on the etiology and pathogenesis of alopecia areata(AA).This paper summarizes the research progress of modern pharmacology of peony and licorice and its clinical application.Clinical research section:Research purpose:To explore the clinical efficacy and clinical safety of the traditional Chinese medicine prescription of "peony and liquorice granule" in the treatment of severe alopecia areata.Research methods:In this experiment,the self-contrast study method of oral "peony and liquorice granule" was used in the patients with severe alopecia areata.The subjects were given a daily dose of "peony and liquorice granule" at 30g per day for 12 weeks.During the treatment period,the patient was revisited every 4 weeks,filling out the case report form(CRF),taking clinical photos,conducting hair mirror detection and receiving the next cycle of drugs.Completed after 12 weeks of treatment,according to the evaluation of patients to fill in"peony and liquorice granule" in the treatment of severe alopecia areata satisfaction,and through the acquisition of hair mirror image,three indicators were analyzed before and after treatment,including the growth of white or black hair,the change of the hair mirror image,and the grading of scalp inflammation.Meanwhile,the improvement of clinical subjective indicators in patients with CRF was analyzed.According to these data,the clinical effect and safety of "peony and liquorice granule" on severe alopecia areata.Research results:?.The patients who participated in this clinical study were mostly male,the onset age was less than 30 years,and there are more children.Seventy percent of the severe bald subjects were brainwork,including students,engineers,and media workers.The subjects'body mass index(BMI)had a two-stage differentiation trend,53%of the total is in the abnormal range,and 63%of the severity of alopecia were classified as S5B2.The TCM syndromes are mainly composed of liver depression,spleen deficiency,liver and kidney deficiency,and humidity and heat accumulation,and 89%of patients have two or three syndromes,and the elderly can easily get stasis.?.The clinical subjective indicators were significantly improved after 12 weeks of treatment of the patients with severe alopecia in the clinical study,and the improvement degree was statistically significant(P<0.001).There were significant improvement in the growth and appearance of hair mirror in patients with severe alopecia areata,and there was a significant difference between the two objective indicators(P<0.001).Another objective indicator showed a slight improvement in the grading of scalp inflammation,with statistical difference(P<0.05).?.The clinical satisfaction rate of the 19 patients with severe alopecia in the study was 42%.?.None of the 19 subjects in this clinical study had any adverse reactions after the oral administration of "peony and liquorice granule",the indexes of ALT,AST and creatinine clearance were not significantly changed before taking the drug,and were in normal range.It was confirmed that the granule had good safety.?.The group of Chinese traditional Chinese medicine "peony and liquorice granule" was established by the treatment principle of nourishing blood,nourishing the liver,nourishing Yin and nourishing the liver and spleen.In clinical treatment,the patient can effectively improve the diet,sleep,mood,and other symptoms,relieve scalp inflammation and promote the growth of hair.Moreover,it has remarkable curative effect on severe alopecia patients with liver depression and spleen deficiency.Conclusion:This experiment was based on Chinese medicine theory,clinical application"peony and liquorice granule" treatment of severe alopecia areata,through clinical found"peony and liquorice granule" has obvious improving patient subjective symptom index,relieve skin inflammation,promoting hair growth,and so on,and no adverse events occurred in the process of research,confirmed that the Chinese medicine granules has higher security."peony and liquorice granule" as modified dosage form of prescriptions in regulating severe alopecia areata patients body balance,promote the hair growth has exact curative effect,worthy of the mechanism of the treatment for further discussion and research.