Clinical Study On TCM Syndromes Of H. Pylori Infection-related Gastric Diseases And Changes In Tongue Image Before And After Treatment

ObjectiveBy analyzing H.pylori related factors of infection,symptoms of syndromes of traditional Chinese medicine distribution,H.pylori tongue changes before and after the treatment of infection,explore H.pylori infection the epidemiological characteristics and the eradication of H.pylori therapy and the correlation of tongue,and to guide clinical diagnosis and treatment.MethodsRegistration form H.pylori treatment,based on the combination of H.pylori based and new developments of clinical epidemiology,to supplement modifications,and in reference to the related literature and comprehensive expertise into the tongue diagnosis and syndrome differentiation of traditional Chinese medicine on the basis of the content;design and develop"H.pylori infection factors affecting research registration form".The complete information was collected from 512 patients who were admitted to the department of integrative TCM and western medicine in the first hospital of Peking University from December 2016 to January 2018 and met the inclusion criteria,using SPSS 20.0 software for statistical analysis.Results1 This study included 512 patients with upper gastrointestinal disorders,including 236 patients with H.pylori,276 patients with H.pylori negative,and 46.9%of H.pylori infection.2 There was no significant difference in H.pylori infection rate among individuals with different genders,ages and educational backgrounds(P>0.05).There was no significant correlation between H.pylori infection and co-resident population(P>0.05).With the increase in the number of cohabitants;the infection rate of H.pylori increased;the nature of the work and whether family members have H.pylori infection was associated with H.pylori infection(P<0.05).3 There was no significant correlation between smoking,drinking and drinking yogurt and H.pylori infection in living eating habits(P>0.05).There was a correlation between eating frequency and H.pylori infection(P<0.05).4 In the study of the correlation between H.pylori infection and disease,there was no significant correlation between oral ulcer,primary hypertension,type 2 diabetes and H.pylori infection(P>0.05).There was a correlation between periodontitis,hyperlipidemia and H.pylori infection(P<0.05).5 The symptoms with higher frequency of H.pylori positive patients were dry mouth>halitosis>mouth bitter>sticky stool>bloating,acid reflux,and the higher frequency of sy-mptoms in H.pylori-negative patients was dry mouth>bloating>acid reflux>Stomachach-e>Mouth bitter>Hemia,heartburn.By comparison,the infection rate of H.pylori was signif icantly different between dry mouth,bitter mouth,bad breath,mouth stickiness,abdominal distension,constipation and sticky stool(P<0.05).The H.pylori infection rate was significa ntly higher in patients with dry mouth,bad breath,mouth pain,mouth stickiness,abdomina 1 distension,and sticky stools than in those without symptoms,whereas the H.pylori infe ction rate was lower in constipation patients.6 The syndrome of H.pylori infection is classified as the spleen and stomach dampnes s syndrome>liver and stomach syndrome>liver qi syndrome>spleen and stomach deficie ncy syndrome>cold and heat syndrome>syndrome of stomach Yin deficiency syndrom e>stomach blood stasis syndrome.The syndrome distribution of H.pylori negative patien ts is the syndrome of spleen and stomach dampness and heat syndrome>liver qi syndr ome>liver and stomach syndrome>syndrome of spleen and stomach deficiency syndrom e>syndrome>syndrome>syndrome(P<0.05).There were significant differences between the two groups(P<0.05).Syndrome type H.pylori detection rate is the syndrome of spleen and stomach dampness syndrome>liver and stomach stagnation syndrome>spleen and st omach deficiency syndrome>cold and heat entrainment syndrome>gastric blood stasis s yndrome>liver qi syndrome>gastric syndrome>gastric syndrome>syndrome of stomach Yin deficiency syndrome.7 There were significant differences in the distribution of tongue color before and after the treatment of 129 patients who had been treated with the eradication of H.pylori(P<0.05).The proportion of red tongue(bright red tongue+dark red tongue+magenta tongue)decreased obviously,and the proportion of reddish tongue increased.There were significant differences in the distribution of tongue coating before and after treatment(P<0.05),and there was a significant difference in the tongue coating color before and after the treatment(P<0.05).The proportion of the yellow tongue coating decreased,the proportion of white tongue coating increased,There was no obvious difference of greasy fur between the treatment before and after treatment(P<0.05).Conclusions1 H.pylori infection rate was high in those who had physical laborers,family patients with H.pylori infection,and more frequent of eating out.2 H.pylori infection was associated with periodontitis and hyperlipidemia.3H.pylori infection was associated with symptoms of dry mouth,mouth pain,bad breath,mouth stickiness,bloating,and sticky stool.Patients with constipation have low H.pylori infection rate.4 H.pylori infection is associated with TCM syndrome type,the infection rate of H.pylori in spleen and stomach heat syndrome was highest.5 There was significant difference in tongue appearance before and after the eradication therapy,after eradication,the proportion of red tongue and yellow moss decreased.