| Epilepsy is a group of chronic brain dysfunction diseasecaused by abnormal discharge of brain neurons generated by different etiologies.It is the most common neurological chronic disease in childhood and causes a heavy burden onpatients and their families.Modern studies have found that the psychological health of women during pregnancy not only has an important influence on the body of pregnant women,but also has a great relationship with the growth and development of the fetus.Chinese medicine theory emphasizes emotional illness and abnormal emotions are common causes of clinical diseases.However,there is currently a lack of knowledge on the relationship between maternal emotions and childhood epilepsy.Objective:1 To explorethe relationship between the change of maternal emotions and childhood epilepsy by a case-control study,so as to provide evidence for the prevention and treatment of epilepsy from the perspective of the etiology of Chinese medicine.2 To explore the relationship between the possible related factors affecting pregnant motherhood and epilepsy in children.Methods:1 ReviewThe first part includes Western medicine's understanding of the causes and treatment of epilepsy and its understanding of emotional illness.The second part is the traditional Chinese medicine literature research to clarify the understanding of ancient physicians on the causes of epilepsy.Epilepsy causes are so complex that ancient physicians have different understanding of their causes,such as congenital,emotional,phlegm and so on.The disease in the brain,and have correlation of the five internal organs.There are similarities with modern medical genetics,brain injury,and systemic disease causes.In order to provide a theoretical basis for clinical research,the third part explores the correlation between maternal emotions and epilepsy in children through the literature research.2 Case-control studyFrom September 2017 to March 2018 in Dongfang Hospital of Beijing University of Chinese Medicine,the Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing Children's Hospital affiliated to Capital Medical University were included in the case study group(epileptic children)and control group(non-epileptic children)according to the inclusion exclusion criteria.Participants all need to sign an informed consent form and fill in the Case Report Form(CRF).The research used three evaluation standards including "Hamilton Depression and Anxiety Scale,""Self rating Depression Scale" and "Life Events Scale".Maternal depression,anxiety,pregnancy negative emotions and negative events were used as exposure factors to calculate the exposure ratios of the case group and the control group respectively,and the odds ratio(OR)was calculated by using Logisic regression analysis.Non-parametric tests were used to balance the distribution of basic characteristics such as age and gender of the two groups.Epidata3.1 and SPSS 20.0 were used for data management and statistical analysis.Result:1 Through literature review,we have clarified Chinese and Western Medicine'Understanding of Epilepsy,and obtained possible risk factors for epileptogenesis.2 A total of 277 patients were recruited in this study,142 wre in the case group and 135 were in the control group.By filling inthe Hamilton Depression and Anxiety Scale,in the case group,91(64%)patients were depressed and 51(36%)patients were not depressed.In the control group,29(21%)were depressed and 106(79%)were without depression.The OR ratio was 6.521[95%CI(1.592-10.473)],which showedthat pregnant mothers with depression had a risk of giving birth to epilepsyis children and was 2.669 times that of whom without depression.It was suggested that maternal depression had a correlation with epilepsy in children.78(55%)patients with anxiety and 66(45%)patients without anxiety in the case group were detected in the Hamilton Anxiety Scale;50(37%)patients were anxious and 85(63%)patients were anxious in the control group.The OR ratio was 1.658[95%CI(1.031-2.666)],which showedthat pregnant mothers with anxious had a risk of giving birth to epilepsyis children and was 1.658 times that of whom without anxiety.It is suggested that maternal anxiety has a correlation with epilepsy in children.3 Self rating Depression Scale(SDS)test showed that there were 25 people with depression and 117 people without depression of the case group.In the control group,there were 15 depression patients and 120 patients without depression(P=0.127>0.05),which showed no statistical significance.The anxiety self-assessment(SAS)test showed that there were 13 patients with anxiety and 129 without anxiety in the case group.In the control group,there were 23 subjects with anxiety and 112 subjects without anxiety(P=0.029<0.05),which showed statistical significance.This study showed that there was no correlation between offspring epilepsy and SDS self-assessment scale results,however correlated with the result of SAS self-assessment scale.4 Life event scale found that there were 9 patients with more than 20 points in the case group and 13 in the control group.Logistic regression analysis showed that P=0..02<0.05,which meant statistical significance.The positive event group P=0.00<0.05,has statistical difference.This study shows that there is a correlation between negative life events during pregnancy and epilepsy in the offspring.5 Multiple regression analysis showed that the multiple regression analysis of parents'education,mother's pregnancy disease,mother's pregnancy,family history of epilepsy,the history of febrile convulsion in the offspring,and the history of traumatic brain injury showed that P<0.05 was statistically significant,which showed that there was a correlation with the occurrence of epilepsy,including pregnancy,pregnancy,and epilepsy.The family history,the history of hyperthermal convulsion in the offspring,and the history of traumatic brain injury were positive correlation,and the parents' educational background was negative correlation,while the P values of perinatal injury were all>0.05,no statistical significance.The results of multiple factors analysis showed no correlation with the generation of offspring epilepsy.The Hamilton depression scale of pregnant women was correlated with the offspring epilepsy,P=0.000,OR=6.084[95%C.I(2.762-13.417)],which was statistically significant,and the two were positively correlated.The negative event score of pregnant women was correlated with the offspring epilepsy,P=0.017<0.05,OR=3.946,[95%C.I(1.272-12.237)],which was statistically significant,and the two were positively correlated.Positive events P=0.026<0.05,OR=0.588[95%C.I(0.275-0.875)]were statistically significant,and the two were negatively correlated.6 Multivariate regression analysis showed that multivariate regression analysis of parental education,maternal pregnancy disease,maternal pregnancy,family history of epilepsy,offspring febrile convulsions,and offspring traumatic brain injury history showed P<0.05,which was statistically significant.There is a correlation with the occurrence of epilepsy,among which pregnancy sickness,maternal pregnancy,family history of epilepsy,offspring febrile seizure history,offspring traumatic brain injury history are positively correlated,parents' education is negatively correlated,and perinatal lesions P values are>0.05,not statistically significant,multivariate analysis showed no correlation with offspring epilepsy.The Hamilton Depression Rating Scale of pregnant mothers was correlated with offspring epilepsy,P=0.000,OR=6.084[95%C.I(2.762-13.417)].There was a statistically significant difference between the two groups.There was a correlation between negative maternal negative event scores and offspring epilepsy,P=0.017<0.05,OR=3.946,[95%C.I(1.272-12.237)],which was statistically significant.Positive events P=0.026<0.05,OR=0.588[95%C.I(0.275-0.875)]were statistically significant,and they were negatively correlated.Conclusion:1 Pediatric epilepsy is associated with the change of maternal emotions.2 Pediatric epilepsy is associated with the negative eventduring pregnancy.3 The possible related factors of Children's epilepsy may including family history,pregnancy,gestational illness and parental education.4 Children with epilepsy can cause depression,anxiety and depression in mothers. |
PDF Full Text Request