| In this study,a randomized controlled clinical study was conducted to objectively evaluate the therapeutic effect of the navel anti-cancer Xiaogu prescription in the treatment of malignant ascites with deficiency of Zhongyang,blood stasis and toxic fluid,and to observe the stability rate of ascites and improve the symptoms of traditional Chinese medicine.Improve the effect of quality of life and observe the safety of drugs.Method:In this study,56 patients who met the inclusion criteria were divided into treatment group and control group according to the principle of random distribution.The treatment group was treated with anti-cancer Xiaogu decoction combined with diuretics,while the control group was treated with diuretic only,with short-term ascites efficacy,TCM syndrome score,quality of life score,24 h urine volume of abdominal circumference change,blood routine,liver and kidney function as the observation index.Both groups were observed 2 weeks later to evaluate the clinical efficacy.Results:(1)Comparison of the maximum depth of ascites dark area:?after treatment,the maximum depth of ascites dark area in the treatment group decreased significantly(P<0.05).while in the control group,the maximum depth of the ascites dark area did not decrease significantly(P>0.05).?Comparison between two groups:The maximum depth of ascites dark area before and after treatment was statistically significant(P<0.05).(2)Comparison of ascites efficacy evaluation:The effective rate was 92.86 in the treatment group and 89.29 in the control group(P>0.05).(3)Numerical comparison of abdominal girth:?The abdominal circumference in the treatment group was decreased compared with that before treatment,and the difference was statistically significant(P<0.05).?The decrease of abdominal circumference in the treatment group was better than that in the control group,and the difference was statistically significant(P<0.05).(4)Comparison of TCM symptoms:The degree of improvement of I TCM symptoms in treatment group,such as bulging,abdominal distension,exposure of green tendons,chills,fatigue,dull complexion,shortness of breath and less food intake,was better than that in the control group(P<0.05).(5)Comparison of TCM Syndromes integral:?Comparison within group:the scores of TCM syndromes in both groups decreased before and after treatment,and the difference was statistically significant(P<0.05).?Comparison between the two groups:The improvement of TCM syndromes in the treatment group was significantly better than that in the control group(P<0.01).(6)Comparison of Therapeutic effects of TCM Syndrome:In the treatment group,20 cases were effective,8 cases were ineffective,and the total effective rate was 71.43.In the control group,the effective cases were 10 cases(35.71%)and 18 cases(64.29%),the total effective rate was 35.71%.The improvement rate of TCM syndrome in the treatment group was significantly better than that in the control group(P<0.01).(7)Quality of life score comparison:?Intragroup comparison:The scores of quality of life in the treatment group were significantly higher than those before treatment(P<0.01),but there was no significant difference in the quality of life score in the control group(P>0.05).?Comparison between groups:The improvement of quality of life in the treatment group was significantly better than that in the control group(P<0.01).(8)Comparison of the efficacy of KPS:In the treatment group,there were 21 cases of improvement(75.00%),3 cases of stability(10.71%),and 4 cases of reduction(14.29%).In the control group,13 cases improved 46.43%,5 cases stabilized 17.86%,10 cases decreased 35.71%.By statistical analysis,the treatment group can significantly improve the quality of life of patients,the difference is statistically significant(P<0.05).(9)Comparison of 24 hours urine volume:?Intragroup comparison:The 24h urine volume in the treatment group was significantly higher than that in the former group(P<0.05),while in the control group,there was no significant change in the 24h urine volume(P>0.05).?Comparison between groups:There was no significant difference in 24h urine volume between the treatment group and the control group(P>0.05).(10)Safety evaluation:?routine blood test:There was no significant difference between the two groups before and after treatment(P>0.05).?Liver function:There was no significant difference between the two groups before and after treatment(P>0.05).?Renal function:There was no significant difference between the two groups before and after treatment(P>0.05).Conclusion:The treatment of malignant ascites with anti-cancer Xiaogu Fang and diuretic can effectively reduce the depth of ascites,relieve clinical symptoms,improve the quality of life of patients,and have better safety.It highlights the advantages of anti-cancer Xiaogu Formula and Western Medicine in the treatment of malignant ascites,which is worthy of further clinical promotion. |
PDF Full Text Request